Transcription complexes recruit a chaperone to perform cotranscriptional processing of tRNA

Nayef Jarrous; Dhivakar Mani

doi:10.1016/j.molcel.2024.01.010

Transcription complexes recruit a chaperone to perform cotranscriptional processing of tRNA

Nayef Jarrous^*, Dhivakar Mani

^*Corresponding author for this work

Department of Microbiology and Molecular Genetics

Research output: Contribution to journal › Comment/debate

Abstract

Leone et al.¹ reveal that Pol III transcription complexes recruit a chaperone, HSP70, to execute cotranscriptional cleavage of precursor tRNA. HSP70 binds to the polymerase and translocates to nascent precursor tRNA and then tRNA. The last complex facilitates Pol III to engage in a new, efficient transcription cycle with another HSP70.

Original language	English
Pages (from-to)	619-620
Number of pages	2
Journal	Molecular Cell
Volume	84
Issue number	4
DOIs	https://doi.org/10.1016/j.molcel.2024.01.010
State	Published - 15 Feb 2024

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© 2024 Elsevier Inc.

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10.1016/j.molcel.2024.01.010

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title = "Transcription complexes recruit a chaperone to perform cotranscriptional processing of tRNA",

abstract = "Leone et al.1 reveal that Pol III transcription complexes recruit a chaperone, HSP70, to execute cotranscriptional cleavage of precursor tRNA. HSP70 binds to the polymerase and translocates to nascent precursor tRNA and then tRNA. The last complex facilitates Pol III to engage in a new, efficient transcription cycle with another HSP70.",

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AB - Leone et al.1 reveal that Pol III transcription complexes recruit a chaperone, HSP70, to execute cotranscriptional cleavage of precursor tRNA. HSP70 binds to the polymerase and translocates to nascent precursor tRNA and then tRNA. The last complex facilitates Pol III to engage in a new, efficient transcription cycle with another HSP70.

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Transcription complexes recruit a chaperone to perform cotranscriptional processing of tRNA

Abstract

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