Transcription regulation in bacteria

Sutharsan Govindarajan, Orna Amster-Choder

Research output: Chapter in Book/Report/Conference proceedingEntry for encyclopedia/dictionarypeer-review


Transcription, the first step in the process of gene expression, is a process during which RNA is synthesized from the complementary DNA strand. RNA polymerase is the central machinery that catalyzes RNA synthesis in a DNA-dependent manner. To initiate transcription, RNA polymerase needs to recognize a region called promoter, which is located upstream of operons/genes. Transcription is tightly regulated through the stages of initiation, elongation and termination. Various factors, including DNA signals, regulatory proteins, noncoding RNAs and small ligands cooperates with RNA polymerase to control transcription. This article reviews our current understanding of transcription regulation in bacteria.

Original languageAmerican English
Title of host publicationEncyclopedia of Microbiology
Number of pages17
ISBN (Electronic)9780128117378
ISBN (Print)9780128117361
StatePublished - 1 Jan 2019

Bibliographical note

Publisher Copyright:
© 2019 Elsevier Inc. All rights reserved.


  • Antitermination
  • Attenuation
  • Backtracking
  • Bacteria
  • Elongation complex
  • Gene regulation
  • Intrinsic terminators
  • Promoter
  • RNA polymerase
  • Replication-transcription conflict
  • Rho (ρ)-dependent terminators
  • Transcription


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