Transcriptional Heterogeneity of Beta Cells in the Intact Pancreas

Lydia Farack; Matan Golan; Adi Egozi; Nili Dezorella; Keren Bahar Halpern; Shani Ben-Moshe; Immacolata Garzilli; Beáta Tóth; Lior Roitman; Valery Krizhanovsky; Shalev Itzkovitz

doi:10.1016/j.devcel.2018.11.001

Transcriptional Heterogeneity of Beta Cells in the Intact Pancreas

Lydia Farack
, Matan Golan
, Adi Egozi
, Nili Dezorella
, Keren Bahar Halpern
, Shani Ben-Moshe
, Immacolata Garzilli
, Beáta Tóth
, Lior Roitman
, Valery Krizhanovsky
, Shalev Itzkovitz^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

68 Scopus citations

Abstract

Using an optimized protocol for single-molecule transcript imaging of the intact pancreas, Farack, Golan, et al. reveal that a small subset of beta cells harbors elevated levels of ribosomes and insulin mRNA, suggesting a sub-specialization in basal insulin secretion.

Original language	English
Pages (from-to)	115-125.e4
Journal	Developmental Cell
Volume	48
Issue number	1
DOIs	https://doi.org/10.1016/j.devcel.2018.11.001
State	Published - 7 Jan 2019
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2018 Elsevier Inc.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

RNA intracellular localization
beta cell heterogeneity
diabetes
insulin secretion
mRNA polarization
pancreas
single molecule Fluorescence in-situ Hybridization

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10.1016/j.devcel.2018.11.001

Cite this

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title = "Transcriptional Heterogeneity of Beta Cells in the Intact Pancreas",

abstract = "Using an optimized protocol for single-molecule transcript imaging of the intact pancreas, Farack, Golan, et al. reveal that a small subset of beta cells harbors elevated levels of ribosomes and insulin mRNA, suggesting a sub-specialization in basal insulin secretion.",

keywords = "RNA intracellular localization, beta cell heterogeneity, diabetes, insulin secretion, mRNA polarization, pancreas, single molecule Fluorescence in-situ Hybridization",

author = "Lydia Farack and Matan Golan and Adi Egozi and Nili Dezorella and \{Bahar Halpern\}, Keren and Shani Ben-Moshe and Immacolata Garzilli and Be{\'a}ta T{\'o}th and Lior Roitman and Valery Krizhanovsky and Shalev Itzkovitz",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

year = "2019",

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doi = "10.1016/j.devcel.2018.11.001",

language = "אנגלית",

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T1 - Transcriptional Heterogeneity of Beta Cells in the Intact Pancreas

AU - Farack, Lydia

AU - Golan, Matan

AU - Egozi, Adi

AU - Dezorella, Nili

AU - Bahar Halpern, Keren

AU - Ben-Moshe, Shani

AU - Garzilli, Immacolata

AU - Tóth, Beáta

AU - Roitman, Lior

AU - Krizhanovsky, Valery

AU - Itzkovitz, Shalev

PY - 2019/1/7

Y1 - 2019/1/7

N2 - Using an optimized protocol for single-molecule transcript imaging of the intact pancreas, Farack, Golan, et al. reveal that a small subset of beta cells harbors elevated levels of ribosomes and insulin mRNA, suggesting a sub-specialization in basal insulin secretion.

AB - Using an optimized protocol for single-molecule transcript imaging of the intact pancreas, Farack, Golan, et al. reveal that a small subset of beta cells harbors elevated levels of ribosomes and insulin mRNA, suggesting a sub-specialization in basal insulin secretion.

KW - RNA intracellular localization

KW - beta cell heterogeneity

KW - diabetes

KW - insulin secretion

KW - mRNA polarization

KW - pancreas

KW - single molecule Fluorescence in-situ Hybridization

UR - https://www.scopus.com/pages/publications/85059604255

U2 - 10.1016/j.devcel.2018.11.001

DO - 10.1016/j.devcel.2018.11.001

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C2 - 30503750

AN - SCOPUS:85059604255

SN - 1534-5807

VL - 48

SP - 115-125.e4

JO - Developmental Cell

JF - Developmental Cell

IS - 1

ER -

Transcriptional Heterogeneity of Beta Cells in the Intact Pancreas

Abstract

Bibliographical note

UN SDGs

Keywords

Access to Document

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