Transcriptional Noise and Somatic Mutations in the Aging Pancreas

Avital Swisa; Klaus H. Kaestner; Yuval Dor

doi:10.1016/j.cmet.2017.11.009

Transcriptional Noise and Somatic Mutations in the Aging Pancreas

Avital Swisa
, Klaus H. Kaestner^*
, Yuval Dor

^*Corresponding author for this work

Research output: Contribution to journal › Short survey › peer-review

8 Scopus citations

Abstract

The underlying mechanisms and functional significance of pancreatic β cell heterogeneity are an intensive area of investigation. In a recent Cell paper, Enge and colleagues (2017) performed single-cell RNA sequencing of human pancreatic cells and concluded that with age, pancreatic cells become transcriptionally noisy and accumulate somatic mutations. The underlying mechanisms and functional significance of pancreatic β cell heterogeneity are an intensive area of investigation. In a recent Cell paper, Enge and colleagues (2017) performed single-cell RNA sequencing of human pancreatic cells and concluded that with age, pancreatic cells become transcriptionally noisy and accumulate somatic mutations.

Original language	English
Pages (from-to)	809-811
Number of pages	3
Journal	Cell Metabolism
Volume	26
Issue number	6
DOIs	https://doi.org/10.1016/j.cmet.2017.11.009
State	Published - 5 Dec 2017

Bibliographical note

Publisher Copyright:
© 2017

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1016/j.cmet.2017.11.009

Cite this

@article{44011f045edc4505b060643539a24386,

title = "Transcriptional Noise and Somatic Mutations in the Aging Pancreas",

abstract = "The underlying mechanisms and functional significance of pancreatic β cell heterogeneity are an intensive area of investigation. In a recent Cell paper, Enge and colleagues (2017) performed single-cell RNA sequencing of human pancreatic cells and concluded that with age, pancreatic cells become transcriptionally noisy and accumulate somatic mutations. The underlying mechanisms and functional significance of pancreatic β cell heterogeneity are an intensive area of investigation. In a recent Cell paper, Enge and colleagues (2017) performed single-cell RNA sequencing of human pancreatic cells and concluded that with age, pancreatic cells become transcriptionally noisy and accumulate somatic mutations.",

author = "Avital Swisa and Kaestner, \{Klaus H.\} and Yuval Dor",

note = "Publisher Copyright: {\textcopyright} 2017",

year = "2017",

month = dec,

day = "5",

doi = "10.1016/j.cmet.2017.11.009",

language = "אנגלית",

volume = "26",

pages = "809--811",

journal = "Cell Metabolism",

issn = "1550-4131",

publisher = "Cell Press",

number = "6",

}

TY - JOUR

T1 - Transcriptional Noise and Somatic Mutations in the Aging Pancreas

AU - Swisa, Avital

AU - Kaestner, Klaus H.

AU - Dor, Yuval

PY - 2017/12/5

Y1 - 2017/12/5

N2 - The underlying mechanisms and functional significance of pancreatic β cell heterogeneity are an intensive area of investigation. In a recent Cell paper, Enge and colleagues (2017) performed single-cell RNA sequencing of human pancreatic cells and concluded that with age, pancreatic cells become transcriptionally noisy and accumulate somatic mutations. The underlying mechanisms and functional significance of pancreatic β cell heterogeneity are an intensive area of investigation. In a recent Cell paper, Enge and colleagues (2017) performed single-cell RNA sequencing of human pancreatic cells and concluded that with age, pancreatic cells become transcriptionally noisy and accumulate somatic mutations.

AB - The underlying mechanisms and functional significance of pancreatic β cell heterogeneity are an intensive area of investigation. In a recent Cell paper, Enge and colleagues (2017) performed single-cell RNA sequencing of human pancreatic cells and concluded that with age, pancreatic cells become transcriptionally noisy and accumulate somatic mutations. The underlying mechanisms and functional significance of pancreatic β cell heterogeneity are an intensive area of investigation. In a recent Cell paper, Enge and colleagues (2017) performed single-cell RNA sequencing of human pancreatic cells and concluded that with age, pancreatic cells become transcriptionally noisy and accumulate somatic mutations.

UR - https://www.scopus.com/pages/publications/85035327905

U2 - 10.1016/j.cmet.2017.11.009

DO - 10.1016/j.cmet.2017.11.009

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.shortsurvey???

C2 - 29211979

AN - SCOPUS:85035327905

SN - 1550-4131

VL - 26

SP - 809

EP - 811

JO - Cell Metabolism

JF - Cell Metabolism

IS - 6

ER -

Transcriptional Noise and Somatic Mutations in the Aging Pancreas

Abstract

Bibliographical note

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this