Transcriptional regulatory networks in Saccharomyces cerevisiae

Tong Ihn Lee, Nicola J. Rinaldi, François Robert, Duncan T. Odom, Ziv Bar-Joseph, Georg K. Gerber, Nancy M. Hannett, Christopher T. Harbison, Craig M. Thompson, Itamar Simon, Julia Zeitlinger, Ezra G. Jennings, Heather L. Murray, D. Benjamin Gordon, Bing Ren, John J. Wyrick, Jean Bosco Tagne, Thomas L. Volkert, Ernest Fraenkel, David K. GiffordRichard A. Young*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2437 Scopus citations

Abstract

We have determined how most of the transcriptional regulators encoded in the eukaryote Saccharomyces cerevisiae associate with genes across the genome in living cells. Just as maps of metabolic networks describe the potential pathways that may be used by a cell to accomplish metabolic processes, this network of regulator-gene interactions describes potential pathways yeast cells can use to regulate global gene expression programs. We use this information to identify network motifs, the simplest units of network architecture, and demonstrate that an automated process can use motifs to assemble a transcriptional regulatory network structure. Our results reveal that eukaryotic cellular functions are highly connected through networks of transcriptional regulators that regulate other transcriptional regulators.

Original languageAmerican English
Pages (from-to)799-804
Number of pages6
JournalScience
Volume298
Issue number5594
DOIs
StatePublished - 25 Oct 2002
Externally publishedYes

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