Transdermal delivery of artemisinins for treatment of pre-clinical cerebral malaria

Johanna Zech, Ron Dzikowski, Karina Simantov, Jacob Golenser*, Karsten Mäder

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Transdermal drug delivery avoids complications related to oral or parenteral delivery - the need for sterility, contamination, gastrointestinal side effects, patient unconsciousness or nausea and compliance. For malaria treatment, we demonstrate successful novel transdermal delivery of artemisone (ART) and artesunate. The incorporation of ART into a microemulsion (ME) overcomes the limitations of the lipophilic drug and provides high transcutaneous bioavailability. ART delivery to the blood (above 500 ng/ml) was proved by examining the sera from treated mice, using a bioassay in cultured Plasmodium falciparum. Skin spraying of ART-ME eliminated P. berghei ANKA in an infected mouse model of cerebral malaria (CM) and prevented CM, even after a late treatment with a relatively small amount of ART (13.3 mg/kg). For comparison, the artesunate (the most used commercial artemisinin) formulation was prepared as ART. However, ART-ME was about three times more efficient than artesunate-ME. The solubility and stability of ART in the ME, taken together with the successful transdermal delivery leading to animal recovery, suggest this formulation as a potential candidate for transdermal treatment of malaria.

Original languageAmerican English
Pages (from-to)148-154
Number of pages7
JournalInternational Journal for Parasitology: Drugs and Drug Resistance
Volume16
DOIs
StatePublished - Aug 2021

Bibliographical note

Publisher Copyright:
© 2021 The Authors

Keywords

  • Artemisinins
  • Cerebral malaria
  • Drug delivery
  • Microemulsion
  • SMEDDS
  • Transdermal delivery

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