Transglutaminase is essential in receptor-mediated endocytosis of α2-macroglobulin and polypeptide hormones

Peter J.A. Davies; Dana R. Davies; Alexander Levitzki; Frederick R. Maxfield; Pierre Milhaud; Mark C. Willingham; Ira H. Pastan

doi:10.1038/283162a0

Transglutaminase is essential in receptor-mediated endocytosis of α₂-macroglobulin and polypeptide hormones

Peter J.A. Davies
, Dana R. Davies
, Alexander Levitzki^*
, Frederick R. Maxfield
, Pierre Milhaud
, Mark C. Willingham
, Ira H. Pastan

^*Corresponding author for this work

Alexander Silberman Institute of Life Sciences

Research output: Contribution to journal › Article › peer-review

426 Scopus citations

Abstract

The receptor-mediated endocytosis of α₂-macroglobulin can be inhibited by a diverse group of chemical compounds all of which share the property of being inhibitors of one form of cellular transglutaminase. The present results strongly suggest that protein cross-linking may be essential for receptor-mediated endocytosis of some protein and polypeptide hormones.

Original language	English
Pages (from-to)	162-167
Number of pages	6
Journal	Nature
Volume	283
Issue number	5743
DOIs	https://doi.org/10.1038/283162a0
State	Published - 1980

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abstract = "The receptor-mediated endocytosis of α2-macroglobulin can be inhibited by a diverse group of chemical compounds all of which share the property of being inhibitors of one form of cellular transglutaminase. The present results strongly suggest that protein cross-linking may be essential for receptor-mediated endocytosis of some protein and polypeptide hormones.",

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AU - Davies, Peter J.A.

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AU - Milhaud, Pierre

AU - Willingham, Mark C.

AU - Pastan, Ira H.

PY - 1980

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AB - The receptor-mediated endocytosis of α2-macroglobulin can be inhibited by a diverse group of chemical compounds all of which share the property of being inhibitors of one form of cellular transglutaminase. The present results strongly suggest that protein cross-linking may be essential for receptor-mediated endocytosis of some protein and polypeptide hormones.

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Transglutaminase is essential in receptor-mediated endocytosis of α₂-macroglobulin and polypeptide hormones

Abstract

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