Biochemistry exhibits an intense dependence on metals. Here we show that during dry-down reactions, zinc and a few other transition metals increase the yield of long histidine-containing depsipeptides, which contain both ester and amide linkages. Our results suggest that interactions of proto-peptides with metal ions influenced early chemical evolution.
Bibliographical noteFunding Information:
This research was supported by the NSF and the NASA Astrobiology Program under the NSF Center for Chemical Evolution [CHE-1504217] and by the NASA Astrobiology Program under the NASA Center for the Origins of Life [80NSSC18K1139]. Moran Frenkel-Pinter acknowledges the NASA postdoctoral fellowship program.
© The Royal Society of Chemistry.