Transition metals enhance prebiotic depsipeptide oligomerization reactions involving histidine

Moran Frenkel-Pinter; Alyssa B. Sargon; Jennifer B. Glass; Nicholas V. Hud; Loren Dean Williams

doi:10.1039/d0ra07965k

Transition metals enhance prebiotic depsipeptide oligomerization reactions involving histidine

Moran Frenkel-Pinter, Alyssa B. Sargon, Jennifer B. Glass, Nicholas V. Hud, Loren Dean Williams^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Biochemistry exhibits an intense dependence on metals. Here we show that during dry-down reactions, zinc and a few other transition metals increase the yield of long histidine-containing depsipeptides, which contain both ester and amide linkages. Our results suggest that interactions of proto-peptides with metal ions influenced early chemical evolution.

Original language	American English
Pages (from-to)	3534-3538
Number of pages	5
Journal	RSC Advances
Volume	11
Issue number	6
DOIs	https://doi.org/10.1039/d0ra07965k
State	Published - 18 Jan 2021
Externally published	Yes

Bibliographical note

Funding Information:
This research was supported by the NSF and the NASA Astrobiology Program under the NSF Center for Chemical Evolution [CHE-1504217] and by the NASA Astrobiology Program under the NASA Center for the Origins of Life [80NSSC18K1139]. Moran Frenkel-Pinter acknowledges the NASA postdoctoral fellowship program.

Publisher Copyright:
© The Royal Society of Chemistry.

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title = "Transition metals enhance prebiotic depsipeptide oligomerization reactions involving histidine",

abstract = "Biochemistry exhibits an intense dependence on metals. Here we show that during dry-down reactions, zinc and a few other transition metals increase the yield of long histidine-containing depsipeptides, which contain both ester and amide linkages. Our results suggest that interactions of proto-peptides with metal ions influenced early chemical evolution.",

author = "Moran Frenkel-Pinter and Sargon, {Alyssa B.} and Glass, {Jennifer B.} and Hud, {Nicholas V.} and Williams, {Loren Dean}",

note = "Funding Information: This research was supported by the NSF and the NASA Astrobiology Program under the NSF Center for Chemical Evolution [CHE-1504217] and by the NASA Astrobiology Program under the NASA Center for the Origins of Life [80NSSC18K1139]. Moran Frenkel-Pinter acknowledges the NASA postdoctoral fellowship program. Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",

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AU - Sargon, Alyssa B.

AU - Glass, Jennifer B.

AU - Hud, Nicholas V.

AU - Williams, Loren Dean

N1 - Funding Information: This research was supported by the NSF and the NASA Astrobiology Program under the NSF Center for Chemical Evolution [CHE-1504217] and by the NASA Astrobiology Program under the NASA Center for the Origins of Life [80NSSC18K1139]. Moran Frenkel-Pinter acknowledges the NASA postdoctoral fellowship program. Publisher Copyright: © The Royal Society of Chemistry.

PY - 2021/1/18

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N2 - Biochemistry exhibits an intense dependence on metals. Here we show that during dry-down reactions, zinc and a few other transition metals increase the yield of long histidine-containing depsipeptides, which contain both ester and amide linkages. Our results suggest that interactions of proto-peptides with metal ions influenced early chemical evolution.

AB - Biochemistry exhibits an intense dependence on metals. Here we show that during dry-down reactions, zinc and a few other transition metals increase the yield of long histidine-containing depsipeptides, which contain both ester and amide linkages. Our results suggest that interactions of proto-peptides with metal ions influenced early chemical evolution.

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JO - RSC Advances

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IS - 6

ER -

Transition metals enhance prebiotic depsipeptide oligomerization reactions involving histidine

Abstract

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