Transition metals enhance prebiotic depsipeptide oligomerization reactions involving histidine

Moran Frenkel-Pinter, Alyssa B. Sargon, Jennifer B. Glass, Nicholas V. Hud, Loren Dean Williams*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Biochemistry exhibits an intense dependence on metals. Here we show that during dry-down reactions, zinc and a few other transition metals increase the yield of long histidine-containing depsipeptides, which contain both ester and amide linkages. Our results suggest that interactions of proto-peptides with metal ions influenced early chemical evolution.

Original languageAmerican English
Pages (from-to)3534-3538
Number of pages5
JournalRSC Advances
Volume11
Issue number6
DOIs
StatePublished - 18 Jan 2021
Externally publishedYes

Bibliographical note

Publisher Copyright:
© The Royal Society of Chemistry.

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