Transition metals enhance prebiotic depsipeptide oligomerization reactions involving histidine

Moran Frenkel-Pinter; Alyssa B. Sargon; Jennifer B. Glass; Nicholas V. Hud; Loren Dean Williams

doi:10.1039/d0ra07965k

Transition metals enhance prebiotic depsipeptide oligomerization reactions involving histidine

Moran Frenkel-Pinter, Alyssa B. Sargon, Jennifer B. Glass, Nicholas V. Hud, Loren Dean Williams^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Biochemistry exhibits an intense dependence on metals. Here we show that during dry-down reactions, zinc and a few other transition metals increase the yield of long histidine-containing depsipeptides, which contain both ester and amide linkages. Our results suggest that interactions of proto-peptides with metal ions influenced early chemical evolution.

Original language	English
Pages (from-to)	3534-3538
Number of pages	5
Journal	RSC Advances
Volume	11
Issue number	6
DOIs	https://doi.org/10.1039/d0ra07965k
State	Published - 18 Jan 2021
Externally published	Yes

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© The Royal Society of Chemistry.

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abstract = "Biochemistry exhibits an intense dependence on metals. Here we show that during dry-down reactions, zinc and a few other transition metals increase the yield of long histidine-containing depsipeptides, which contain both ester and amide linkages. Our results suggest that interactions of proto-peptides with metal ions influenced early chemical evolution.",

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AU - Williams, Loren Dean

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AB - Biochemistry exhibits an intense dependence on metals. Here we show that during dry-down reactions, zinc and a few other transition metals increase the yield of long histidine-containing depsipeptides, which contain both ester and amide linkages. Our results suggest that interactions of proto-peptides with metal ions influenced early chemical evolution.

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Transition metals enhance prebiotic depsipeptide oligomerization reactions involving histidine

Abstract

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