Translating solution to solid phase glycosylation conditions

Yasmeen Bakhatan; Dror Ben Abba Amiel; Yonatan Sukhran; Chieh Kai Chan; Wei Chih Lo; Po Wei Lu; Pin Hsuan Liao; Cheng Chung Wang; Mattan Hurevich

doi:10.1039/d2cc03831e

Translating solution to solid phase glycosylation conditions

Yasmeen Bakhatan, Dror Ben Abba Amiel, Yonatan Sukhran, Chieh Kai Chan, Wei Chih Lo, Po Wei Lu, Pin Hsuan Liao, Cheng Chung Wang, Mattan Hurevich^*

^*Corresponding author for this work

Institute of Chemistry

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Optimization of glycosylation conditions for automated glycan assembly is highly challenging, demands wasteful use of precious building blocks, and relies on nontrivial analyses. We developed a semi-quantitative method for automated optimization of glycosylation temperature that utilized minute quantities of donors and translated those conditions to solid-phase glycan assembly.

Original language	English
Pages (from-to)	11256-11259
Number of pages	4
Journal	Chemical Communications
Volume	58
Issue number	80
DOIs	https://doi.org/10.1039/d2cc03831e
State	Published - 8 Sep 2022

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© 2022 The Royal Society of Chemistry.

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AU - Bakhatan, Yasmeen

AU - Ben Abba Amiel, Dror

AU - Sukhran, Yonatan

AU - Chan, Chieh Kai

AU - Lo, Wei Chih

AU - Lu, Po Wei

AU - Liao, Pin Hsuan

AU - Wang, Cheng Chung

AU - Hurevich, Mattan

PY - 2022/9/8

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Translating solution to solid phase glycosylation conditions

Abstract

Bibliographical note

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