Translating solution to solid phase glycosylation conditions

Yasmeen Bakhatan; Dror Ben Abba Amiel; Yonatan Sukhran; Chieh Kai Chan; Wei Chih Lo; Po Wei Lu; Pin Hsuan Liao; Cheng Chung Wang; Mattan Hurevich

doi:10.1039/d2cc03831e

Translating solution to solid phase glycosylation conditions

Yasmeen Bakhatan
, Dror Ben Abba Amiel
, Yonatan Sukhran
, Chieh Kai Chan
, Wei Chih Lo
, Po Wei Lu
, Pin Hsuan Liao
, Cheng Chung Wang
, Mattan Hurevich^*

^*Corresponding author for this work

Institute of Chemistry

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Optimization of glycosylation conditions for automated glycan assembly is highly challenging, demands wasteful use of precious building blocks, and relies on nontrivial analyses. We developed a semi-quantitative method for automated optimization of glycosylation temperature that utilized minute quantities of donors and translated those conditions to solid-phase glycan assembly.

Original language	English
Pages (from-to)	11256-11259
Number of pages	4
Journal	Chemical Communications
Volume	58
Issue number	80
DOIs	https://doi.org/10.1039/d2cc03831e
State	Published - 8 Sep 2022

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© 2022 The Royal Society of Chemistry.

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10.1039/d2cc03831e

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abstract = "Optimization of glycosylation conditions for automated glycan assembly is highly challenging, demands wasteful use of precious building blocks, and relies on nontrivial analyses. We developed a semi-quantitative method for automated optimization of glycosylation temperature that utilized minute quantities of donors and translated those conditions to solid-phase glycan assembly.",

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AU - Bakhatan, Yasmeen

AU - Ben Abba Amiel, Dror

AU - Sukhran, Yonatan

AU - Chan, Chieh Kai

AU - Lo, Wei Chih

AU - Lu, Po Wei

AU - Liao, Pin Hsuan

AU - Wang, Cheng Chung

AU - Hurevich, Mattan

PY - 2022/9/8

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AB - Optimization of glycosylation conditions for automated glycan assembly is highly challenging, demands wasteful use of precious building blocks, and relies on nontrivial analyses. We developed a semi-quantitative method for automated optimization of glycosylation temperature that utilized minute quantities of donors and translated those conditions to solid-phase glycan assembly.

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Translating solution to solid phase glycosylation conditions

Abstract

Bibliographical note

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