Transmission electron microscopy of reparative dentin in rat molar pulps

J. Sela*, I. Tamari, Z. Hirschfeld, I. Bab

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

A reparative dentin bridge was induced in rat molar teeth by pulp exposure and capping with calcium hydroxide. Transmission electron-microscopic examination after 10 days revealed the presence of odontoblastic cells and collagenous matrix with focal calcifications. The calcifying fronts were composed of hydroxyapatite crystals. Numerous extracellular matrix vesicles were scattered between the forming cells and the calcifying fronts. Some of the vesicles contained electron-dense material and in others, apatite crystals were detected. Matrix vesicles could not be identified in normal, mature calcifying dentin matrix. In view of the present observations and studies on surgical manipulations in articular cartilage, it is concluded that matrix vesicle calcification may result from alterations in the metabolic state of mesenschymal tissues. These changes can be induced surgically or chemically.

Original languageEnglish
Pages (from-to)109-251
Number of pages143
JournalCells Tissues Organs
Volume109
Issue number3
DOIs
StatePublished - 1981

Keywords

  • Matrix vesicles
  • Reparative dentin

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