Transplantation of allogeneic lymphoid cells specifically depleted of graft versus host reactive cells

Benjamin Bonavida*, Eli Kedar

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

GRAFT versus host (GvH) disease has been a major problem in the transplantation of allogeneic haematopoietic or immunocompetent lymphoid cells. In man, attempts to reduce the GvH effect of transplanted allogeneic cells, including HL-A matching1,2, cell separation techniques3, anti-lymphocyte globulin4, and injection of small doses of bone marrow cells5, have aided successful bone marrow transplantation. Various techniques have been used in animal systems6-14 to reduce the GvH reaction by removing reactive cells from populations of lymphoid cells. So far, however, there has been no attempt to assess the potential value of such specifically depleted cells in transplantation.

Original languageEnglish
Pages (from-to)658-659
Number of pages2
JournalNature
Volume249
Issue number5458
DOIs
StatePublished - 1974
Externally publishedYes

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