Treatment of a multiple sclerosis animal model by a novel nanodrop formulation of a natural antioxidant

Orli Binyamin, Liraz Larush, Kati Frid, Guy Keller, Yael Friedman-Levi, Haim Ovadia, Oded Abramsky, Shlomo Magdassi, Ruth Gabizon*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

53 Scopus citations

Abstract

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system and is associated with demyelination, neurodegeneration, and sensitivity to oxidative stress. In this work, we administered a nanodroplet formulation of pomegranate seed oil (PSO), denominated Nano-PSO, to mice induced for experimental autoimmune encephalomyelitis (EAE), an established model of MS. PSO comprises high levels of punicic acid, a unique polyunsaturated fatty acid considered as one of the strongest natural antioxidants. We show here that while EAE-induced mice treated with natural PSO presented some reduction in disease burden, this beneficial effect increased significantly when EAE mice were treated with Nano-PSO of specific size nanodroplets at much lower concentrations of the oil. Pathological examinations revealed that Nano-PSO administration dramatically reduced demyelination and oxidation of lipids in the brains of the affected animals, which are hallmarks of this severe neurological disease. We propose that novel formulations of natural antioxidants such as Nano-PSO may be considered for the treatment of patients suffering from demyelinating diseases. On the mechanistic side, our results demonstrate that lipid oxidation may be a seminal feature in both demyelination and neurodegeneration.

Original languageAmerican English
Pages (from-to)7165-7174
Number of pages10
JournalInternational Journal of Nanomedicine
Volume10
DOIs
StatePublished - 20 Nov 2015

Bibliographical note

Publisher Copyright:
© 2015 Binyamin et al.

Keywords

  • EAE
  • Nanodrops
  • Neurodegeneration
  • Oxidative stress
  • PSO

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