TY - JOUR
T1 - Treatment of malaria in a mouse model by intranasal drug administration
AU - Touitou, Elka
AU - Waknine, Judith H.
AU - Godin, Biana
AU - Golenser, Jacob
PY - 2006/12
Y1 - 2006/12
N2 - The goal of this work was to investigate intranasal dihydroartemisinin (DHA) delivery as a non-invasive method for treatment of malaria. ICR female mice were infected with Plasmodium berghei ANKA, a model for severe malaria with similarities to the human disease. DHA, at a dose of 2 × 5 mg/kg/day, was administered to mice either intranasally or i.p. Two dosage regimens were tested: prophylaxis and treatment. Parasitemia was monitored every other day, from the time of infection, by thin smears prepared from tail blood. The survival rates in prophylaxis and treatment regimens were 93% and 75%, respectively, for intranasal DHA and this route was at least as effective as the i.p. route used for comparison. All mice in the untreated control and placebo groups succumbed due to the parasitemia. The results show that DHA nasal administration to mice was highly efficient in the treatment of Plasmodium infection in infected rodents. This novel mode of drug administration may be considered as an alternative to conventional treatment.
AB - The goal of this work was to investigate intranasal dihydroartemisinin (DHA) delivery as a non-invasive method for treatment of malaria. ICR female mice were infected with Plasmodium berghei ANKA, a model for severe malaria with similarities to the human disease. DHA, at a dose of 2 × 5 mg/kg/day, was administered to mice either intranasally or i.p. Two dosage regimens were tested: prophylaxis and treatment. Parasitemia was monitored every other day, from the time of infection, by thin smears prepared from tail blood. The survival rates in prophylaxis and treatment regimens were 93% and 75%, respectively, for intranasal DHA and this route was at least as effective as the i.p. route used for comparison. All mice in the untreated control and placebo groups succumbed due to the parasitemia. The results show that DHA nasal administration to mice was highly efficient in the treatment of Plasmodium infection in infected rodents. This novel mode of drug administration may be considered as an alternative to conventional treatment.
KW - Dihydroartemisinin
KW - Drug delivery
KW - Intranasal administration
KW - Malaria
KW - Plasmodium infection
UR - http://www.scopus.com/inward/record.url?scp=33750967374&partnerID=8YFLogxK
U2 - 10.1016/j.ijpara.2006.07.006
DO - 10.1016/j.ijpara.2006.07.006
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C2 - 16942770
AN - SCOPUS:33750967374
SN - 0020-7519
VL - 36
SP - 1493
EP - 1498
JO - International Journal for Parasitology
JF - International Journal for Parasitology
IS - 14
ER -