TY - JOUR
T1 - Treatment of oral mucosal manifestations of chronic graft-versus-host disease
T2 - dexamethasone vs. budesonide
AU - Zadik, Yehuda
AU - Elad, Sharon
AU - Shapira, Anat
AU - Shapira, Michael Y.
N1 - Publisher Copyright:
© 2017 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2017/2/11
Y1 - 2017/2/11
N2 - Introduction: The oral mucosa is commonly involved in chronic graft-versus-host disease (cGVHD). Oral mucosal cGVHD markedly affect individual’s daily function and wellbeing. In some cases, it might become a life threating complication. Areas covered: This article describes the rationale for treatment, method of topical application in the oral cavity, evidence supporting the topical administration of dexamethasone and budesonide for oral cGVHD, and their adverse effects. Expert opinion: Evidence supports the use of topical dexamethasone and budesonide for treatment of oral cGVHD. Topical corticosteroid choice for oral cGVHD, takes into consideration the potency, bioavailability, preferred concentration, and possible adverse effects. Budesonide’s pharmacological characteristics mark it as a preferable topical agent for oral cGVHD.
AB - Introduction: The oral mucosa is commonly involved in chronic graft-versus-host disease (cGVHD). Oral mucosal cGVHD markedly affect individual’s daily function and wellbeing. In some cases, it might become a life threating complication. Areas covered: This article describes the rationale for treatment, method of topical application in the oral cavity, evidence supporting the topical administration of dexamethasone and budesonide for oral cGVHD, and their adverse effects. Expert opinion: Evidence supports the use of topical dexamethasone and budesonide for treatment of oral cGVHD. Topical corticosteroid choice for oral cGVHD, takes into consideration the potency, bioavailability, preferred concentration, and possible adverse effects. Budesonide’s pharmacological characteristics mark it as a preferable topical agent for oral cGVHD.
KW - Budesonide
KW - chronic graft-versus-host disease
KW - dexamethasone
KW - hematopoietic stem cell transplantation
KW - mucosa
KW - oral
KW - oral medicine
KW - pain
UR - http://www.scopus.com/inward/record.url?scp=85011844345&partnerID=8YFLogxK
U2 - 10.1080/14656566.2017.1282464
DO - 10.1080/14656566.2017.1282464
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C2 - 28081677
AN - SCOPUS:85011844345
SN - 1465-6566
VL - 18
SP - 235
EP - 242
JO - Expert Opinion on Pharmacotherapy
JF - Expert Opinion on Pharmacotherapy
IS - 3
ER -