TY - JOUR
T1 - Trichothecene-induced hemolysis. I. The hemolytic activity of T-2 toxin
AU - Segal, Ruth
AU - Milo-Goldzweig, Ilana
AU - Joffe, Avram Z.
AU - Yagen, Boris
PY - 1983/9/30
Y1 - 1983/9/30
N2 - In the present investigation, the hemolytic properties of T-2 toxin were examined. Tests with different concentrations of T-2 toxin showed that essentially complete hemolysis of rat erythrocytes commenced after a lag period, the length of which depended on the concentration of toxin. Comparison of the characteristics of hemolysis caused by T-2 toxin, saponins, H2O2, and polyoxyethylene surfactants showed great similarity between T-2 toxin and the latter two which proceed by a free radical mechanism. The same mechanism was suggested for hemolysis caused by T-2 toxin on the basis of the additional following observations: (1) darkness inhibited hemolysis; (2) specific free radical scavengers, i.e., vitamin E, mannitol, and histidine, inhibited hemolysis caused by T-2 toxin.
AB - In the present investigation, the hemolytic properties of T-2 toxin were examined. Tests with different concentrations of T-2 toxin showed that essentially complete hemolysis of rat erythrocytes commenced after a lag period, the length of which depended on the concentration of toxin. Comparison of the characteristics of hemolysis caused by T-2 toxin, saponins, H2O2, and polyoxyethylene surfactants showed great similarity between T-2 toxin and the latter two which proceed by a free radical mechanism. The same mechanism was suggested for hemolysis caused by T-2 toxin on the basis of the additional following observations: (1) darkness inhibited hemolysis; (2) specific free radical scavengers, i.e., vitamin E, mannitol, and histidine, inhibited hemolysis caused by T-2 toxin.
UR - http://www.scopus.com/inward/record.url?scp=0021039343&partnerID=8YFLogxK
U2 - 10.1016/0041-008X(83)90152-7
DO - 10.1016/0041-008X(83)90152-7
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C2 - 6636168
AN - SCOPUS:0021039343
SN - 0041-008X
VL - 70
SP - 343
EP - 349
JO - Toxicology and Applied Pharmacology
JF - Toxicology and Applied Pharmacology
IS - 3
ER -