Trichothecene-induced hemolysis. I. The hemolytic activity of T-2 toxin

Ruth Segal; Ilana Milo-Goldzweig; Avram Z. Joffe; Boris Yagen

doi:10.1016/0041-008X(83)90152-7

Trichothecene-induced hemolysis. I. The hemolytic activity of T-2 toxin

Ruth Segal^*
, Ilana Milo-Goldzweig
, Avram Z. Joffe
, Boris Yagen

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

72 Scopus citations

Abstract

In the present investigation, the hemolytic properties of T-2 toxin were examined. Tests with different concentrations of T-2 toxin showed that essentially complete hemolysis of rat erythrocytes commenced after a lag period, the length of which depended on the concentration of toxin. Comparison of the characteristics of hemolysis caused by T-2 toxin, saponins, H₂O₂, and polyoxyethylene surfactants showed great similarity between T-2 toxin and the latter two which proceed by a free radical mechanism. The same mechanism was suggested for hemolysis caused by T-2 toxin on the basis of the additional following observations: (1) darkness inhibited hemolysis; (2) specific free radical scavengers, i.e., vitamin E, mannitol, and histidine, inhibited hemolysis caused by T-2 toxin.

Original language	English
Pages (from-to)	343-349
Number of pages	7
Journal	Toxicology and Applied Pharmacology
Volume	70
Issue number	3
DOIs	https://doi.org/10.1016/0041-008X(83)90152-7
State	Published - 30 Sep 1983

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AU - Segal, Ruth

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AU - Joffe, Avram Z.

AU - Yagen, Boris

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AB - In the present investigation, the hemolytic properties of T-2 toxin were examined. Tests with different concentrations of T-2 toxin showed that essentially complete hemolysis of rat erythrocytes commenced after a lag period, the length of which depended on the concentration of toxin. Comparison of the characteristics of hemolysis caused by T-2 toxin, saponins, H2O2, and polyoxyethylene surfactants showed great similarity between T-2 toxin and the latter two which proceed by a free radical mechanism. The same mechanism was suggested for hemolysis caused by T-2 toxin on the basis of the additional following observations: (1) darkness inhibited hemolysis; (2) specific free radical scavengers, i.e., vitamin E, mannitol, and histidine, inhibited hemolysis caused by T-2 toxin.

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Trichothecene-induced hemolysis. I. The hemolytic activity of T-2 toxin

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