Tricyclic antidepressant drugs as antagonists of muscarinic receptors in sympathetic ganglia

Marta Weinstock*, Dvora Cohen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Close arterial injection of McN-A-343 into the superior cervical ganglion of the cat resulted in contractions of the nictitating membrane. The ganglionic effects of McN-A-343 but not those of DMPP were antagonised in a dose-related manner by 2-10 μg of desipramine, imipramine, chlorimipramine, iprindole and viloxazine. No correlation was found between the dose of each drug which blocked the effects of McN-A-343 and that required to potentiate the responses of the nictitating membrane to intra-arterial administration of noradrenaline. It is concluded that clinically effective antidepressant agents can block muscarinic receptors in neural tissue, even if they do not do so in smooth muscle and gland cells.

Original languageEnglish
Pages (from-to)321-328
Number of pages8
JournalEuropean Journal of Pharmacology
Volume40
Issue number2
DOIs
StatePublished - Dec 1976
Externally publishedYes

Keywords

  • Chlorimipramine
  • Desipramine
  • Imipramine
  • Iprindole
  • McN-A-343 antagonism in ganglia
  • Noradrenaline potentiation
  • Viloxazine

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