Triggered Dimerization and Trimerization of DNA Tetrahedra for Multiplexed miRNA Detection and Imaging of Cancer Cells

Zhixin Zhou; Daoqing Fan; Jianbang Wang; Yang Sung Sohn; Rachel Nechushtai; Itamar Willner

doi:10.1002/smll.202007355

Triggered Dimerization and Trimerization of DNA Tetrahedra for Multiplexed miRNA Detection and Imaging of Cancer Cells

Zhixin Zhou, Daoqing Fan, Jianbang Wang, Yang Sung Sohn, Rachel Nechushtai, Itamar Willner^*

^*Corresponding author for this work

Department of Plant and Environmental Sciences (Natural Sciences)

Research output: Contribution to journal › Review article › peer-review

46 Scopus citations

Abstract

The reversible and switchable triggered reconfiguration of tetrahedra nanostructures from monomer tetrahedra structures into dimer or trimer structures is introduced. The triggered bridging of monomer tetrahedra by K⁺-ion-stabilized G-quadruplexes or T-A•T triplexes leads to dimer or trimer tetrahedra structures that are separated by crown ether or basic pH conditions, respectively. The signal-triggered dimerization/trimerization of DNA tetrahedra structures is used to develop multiplexed miRNA-sensing platforms, and the tetrahedra mixture is used for intracellular sensing and imaging of miRNAs.

Original language	English
Article number	2007355
Journal	Small
Volume	17
Issue number	6
DOIs	https://doi.org/10.1002/smll.202007355
State	Published - 11 Feb 2021

Bibliographical note

Publisher Copyright:
© 2021 Wiley-VCH GmbH

Keywords

DNA nanotechnology
G-quadruplexes
fluorescence
logic gates
sensors
triplexes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/smll.202007355

Cite this

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abstract = "The reversible and switchable triggered reconfiguration of tetrahedra nanostructures from monomer tetrahedra structures into dimer or trimer structures is introduced. The triggered bridging of monomer tetrahedra by K+-ion-stabilized G-quadruplexes or T-A•T triplexes leads to dimer or trimer tetrahedra structures that are separated by crown ether or basic pH conditions, respectively. The signal-triggered dimerization/trimerization of DNA tetrahedra structures is used to develop multiplexed miRNA-sensing platforms, and the tetrahedra mixture is used for intracellular sensing and imaging of miRNAs.",

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AU - Sohn, Yang Sung

AU - Nechushtai, Rachel

AU - Willner, Itamar

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Triggered Dimerization and Trimerization of DNA Tetrahedra for Multiplexed miRNA Detection and Imaging of Cancer Cells

Abstract

Bibliographical note

Keywords

UN SDGs

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