Triggered release of aqueous content from liposome-derived sol-gel nanocapsules

Yael Steinberg; Avi Schroeder; Yeshayahu Talmon; Judith Schmidt; Rafail L. Khalfin; Yachin Cohen; Jean Marie Devoisselle; Sylvie Begu; David Avnir

doi:10.1021/la702311f

Triggered release of aqueous content from liposome-derived sol-gel nanocapsules

Yael Steinberg, Avi Schroeder, Yeshayahu Talmon, Judith Schmidt, Rafail L. Khalfin, Yachin Cohen, Jean Marie Devoisselle, Sylvie Begu, David Avnir^*

^*Corresponding author for this work

Institute of Chemistry

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Liposomes prepared from a mixture of L-α- dipalmitoylphosphatidylcholine and the PEGilated phospholipid N-(carbonylmethoxypoly(ethylene glycol 2000))-1,2-distearoyl-sn-glycero-3- phosphoethanolamine were used as templates for the production of silica and alkylated silica ∼100 nm capsules, "liposils", entrapping aqueous solutions of anionic dyes. Triggered release of this content was successfully affected by either low-frequency ultrasound or by microwave treatments. Cryo-TEM was used to follow the formation process of these particles, which are aggregated in a chain-like manner. A mechanism explaining this phenomenon is suggested.

Original language	English
Pages (from-to)	12024-12031
Number of pages	8
Journal	Langmuir
Volume	23
Issue number	24
DOIs	https://doi.org/10.1021/la702311f
State	Published - 20 Nov 2007

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abstract = "Liposomes prepared from a mixture of L-α- dipalmitoylphosphatidylcholine and the PEGilated phospholipid N-(carbonylmethoxypoly(ethylene glycol 2000))-1,2-distearoyl-sn-glycero-3- phosphoethanolamine were used as templates for the production of silica and alkylated silica ∼100 nm capsules, {"}liposils{"}, entrapping aqueous solutions of anionic dyes. Triggered release of this content was successfully affected by either low-frequency ultrasound or by microwave treatments. Cryo-TEM was used to follow the formation process of these particles, which are aggregated in a chain-like manner. A mechanism explaining this phenomenon is suggested.",

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T1 - Triggered release of aqueous content from liposome-derived sol-gel nanocapsules

AU - Steinberg, Yael

AU - Schroeder, Avi

AU - Talmon, Yeshayahu

AU - Schmidt, Judith

AU - Khalfin, Rafail L.

AU - Cohen, Yachin

AU - Devoisselle, Jean Marie

AU - Begu, Sylvie

AU - Avnir, David

PY - 2007/11/20

Y1 - 2007/11/20

N2 - Liposomes prepared from a mixture of L-α- dipalmitoylphosphatidylcholine and the PEGilated phospholipid N-(carbonylmethoxypoly(ethylene glycol 2000))-1,2-distearoyl-sn-glycero-3- phosphoethanolamine were used as templates for the production of silica and alkylated silica ∼100 nm capsules, "liposils", entrapping aqueous solutions of anionic dyes. Triggered release of this content was successfully affected by either low-frequency ultrasound or by microwave treatments. Cryo-TEM was used to follow the formation process of these particles, which are aggregated in a chain-like manner. A mechanism explaining this phenomenon is suggested.

AB - Liposomes prepared from a mixture of L-α- dipalmitoylphosphatidylcholine and the PEGilated phospholipid N-(carbonylmethoxypoly(ethylene glycol 2000))-1,2-distearoyl-sn-glycero-3- phosphoethanolamine were used as templates for the production of silica and alkylated silica ∼100 nm capsules, "liposils", entrapping aqueous solutions of anionic dyes. Triggered release of this content was successfully affected by either low-frequency ultrasound or by microwave treatments. Cryo-TEM was used to follow the formation process of these particles, which are aggregated in a chain-like manner. A mechanism explaining this phenomenon is suggested.

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Triggered release of aqueous content from liposome-derived sol-gel nanocapsules

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