Tryptase, a novel link between allergic inflammation and fibrosis

Francesca Levi-Schaffer*, Adrian M. Piliponsky

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

88 Scopus citations

Abstract

Allergy is a complex inflammatory disease, the etiology of which is well defined. It has recently been proposed that eosinophil, mast-cell and fibroblast interactions contribute to allergy perpetuation. Moreover, mast-cell-derived tryptase might act as a link among these cells. This hypothesis is supported by two recent papers that show that tryptase, seemingly through the protease-activated receptor-2, mediates eosinophil infiltration in the airways and fibroblast proliferation that depends on both cyclooxygenase and prostaglandin synthesis.

Original languageAmerican English
Pages (from-to)158-161
Number of pages4
JournalTrends in Immunology
Volume24
Issue number4
DOIs
StatePublished - 1 Apr 2003

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