Tryptase activates peripheral blood mononuclear cells causing the synthesis and release of TNF-α, IL-6 and IL-1β: Possible relevance to multiple sclerosis

Vivian Malamud; Ady Vaaknin; Oded Abramsky; Michal Mor; Laurence E. Burgess; Ahmi Ben-Yehudah; Haya Lorberboum-Galski

doi:10.1016/S0165-5728(03)00090-0

Tryptase activates peripheral blood mononuclear cells causing the synthesis and release of TNF-α, IL-6 and IL-1β: Possible relevance to multiple sclerosis

Vivian Malamud, Ady Vaaknin, Oded Abramsky, Michal Mor, Laurence E. Burgess, Ahmi Ben-Yehudah, Haya Lorberboum-Galski^*

^*Corresponding author for this work

Department of Biochemistry and Molecular Biology

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

Presence of mast cells and an increase in the concentration of their products has been reported in multiple sclerosis (MS) plaques. The most abundant secretory mediator of the human mast cell is the tetrameric protease tryptase. We demonstrate that tryptase can activate peripheral mononuclear cells (PBMCs), isolated from healthy donors as well as MS patients for the release of tumor necrosis factor-α (TNF-α), interleukin (IL)-6 and IL-1β. Cytokine secretion was significantly higher in secondary progressive (SP) MS patients and healthy control (HC) individuals than in relapsing-remitting (RR) patients. Our findings suggest that tryptase is, most probably, an important mediator of inflammation in MS.

Original language	English
Pages (from-to)	115-122
Number of pages	8
Journal	Journal of Neuroimmunology
Volume	138
Issue number	1-2
DOIs	https://doi.org/10.1016/S0165-5728(03)00090-0
State	Published - May 2003

Keywords

Cytokines
Multiple sclerosis
Peripheral blood mononuclear cells
Tryptase

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S0165-5728(03)00090-0

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title = "Tryptase activates peripheral blood mononuclear cells causing the synthesis and release of TNF-α, IL-6 and IL-1β: Possible relevance to multiple sclerosis",

abstract = "Presence of mast cells and an increase in the concentration of their products has been reported in multiple sclerosis (MS) plaques. The most abundant secretory mediator of the human mast cell is the tetrameric protease tryptase. We demonstrate that tryptase can activate peripheral mononuclear cells (PBMCs), isolated from healthy donors as well as MS patients for the release of tumor necrosis factor-α (TNF-α), interleukin (IL)-6 and IL-1β. Cytokine secretion was significantly higher in secondary progressive (SP) MS patients and healthy control (HC) individuals than in relapsing-remitting (RR) patients. Our findings suggest that tryptase is, most probably, an important mediator of inflammation in MS.",

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author = "Vivian Malamud and Ady Vaaknin and Oded Abramsky and Michal Mor and Burgess, {Laurence E.} and Ahmi Ben-Yehudah and Haya Lorberboum-Galski",

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AU - Malamud, Vivian

AU - Vaaknin, Ady

AU - Abramsky, Oded

AU - Mor, Michal

AU - Burgess, Laurence E.

AU - Ben-Yehudah, Ahmi

AU - Lorberboum-Galski, Haya

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AB - Presence of mast cells and an increase in the concentration of their products has been reported in multiple sclerosis (MS) plaques. The most abundant secretory mediator of the human mast cell is the tetrameric protease tryptase. We demonstrate that tryptase can activate peripheral mononuclear cells (PBMCs), isolated from healthy donors as well as MS patients for the release of tumor necrosis factor-α (TNF-α), interleukin (IL)-6 and IL-1β. Cytokine secretion was significantly higher in secondary progressive (SP) MS patients and healthy control (HC) individuals than in relapsing-remitting (RR) patients. Our findings suggest that tryptase is, most probably, an important mediator of inflammation in MS.

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KW - Peripheral blood mononuclear cells

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Tryptase activates peripheral blood mononuclear cells causing the synthesis and release of TNF-α, IL-6 and IL-1β: Possible relevance to multiple sclerosis

Abstract

Keywords

UN SDGs

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