Tryptase activates peripheral blood mononuclear cells causing the synthesis and release of TNF-α, IL-6 and IL-1β: Possible relevance to multiple sclerosis

Vivian Malamud, Ady Vaaknin, Oded Abramsky, Michal Mor, Laurence E. Burgess, Ahmi Ben-Yehudah, Haya Lorberboum-Galski*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

60 Scopus citations

Abstract

Presence of mast cells and an increase in the concentration of their products has been reported in multiple sclerosis (MS) plaques. The most abundant secretory mediator of the human mast cell is the tetrameric protease tryptase. We demonstrate that tryptase can activate peripheral mononuclear cells (PBMCs), isolated from healthy donors as well as MS patients for the release of tumor necrosis factor-α (TNF-α), interleukin (IL)-6 and IL-1β. Cytokine secretion was significantly higher in secondary progressive (SP) MS patients and healthy control (HC) individuals than in relapsing-remitting (RR) patients. Our findings suggest that tryptase is, most probably, an important mediator of inflammation in MS.

Original languageAmerican English
Pages (from-to)115-122
Number of pages8
JournalJournal of Neuroimmunology
Volume138
Issue number1-2
DOIs
StatePublished - May 2003

Keywords

  • Cytokines
  • Multiple sclerosis
  • Peripheral blood mononuclear cells
  • Tryptase

Fingerprint

Dive into the research topics of 'Tryptase activates peripheral blood mononuclear cells causing the synthesis and release of TNF-α, IL-6 and IL-1β: Possible relevance to multiple sclerosis'. Together they form a unique fingerprint.

Cite this