TY - JOUR
T1 - Tuberculosis
T2 - From prehistory to Robert Koch, as revealed by ancient DNA
AU - Donoghue, Helen D.
AU - Spigelman, Mark
AU - Greenblatt, Charles L.
AU - Lev-Maor, Galit
AU - Kahila Bar-Gal, Gila
AU - Matheson, Carney
AU - Vernon, Kim
AU - Nerlich, Andreas G.
AU - Zink, Albert R.
PY - 2004/9/1
Y1 - 2004/9/1
N2 - During the past 10 years palaeomicrobiology, a new scientific discipline, has developed. The study of ancient pathogens by direct detection of their DNA has answered several historical questions and shown changes to pathogens over time. However, ancient DNA (aDNA) continues to be controversial and great care is needed to provide valid data. Here we review the most successful application of the technology, which is the study of tuberculosis. This has provided direct support for the current theory of Mycobacterium tuberculosis evolution, and suggests areas of investigation for the interaction of M tuberculosis with its host.
AB - During the past 10 years palaeomicrobiology, a new scientific discipline, has developed. The study of ancient pathogens by direct detection of their DNA has answered several historical questions and shown changes to pathogens over time. However, ancient DNA (aDNA) continues to be controversial and great care is needed to provide valid data. Here we review the most successful application of the technology, which is the study of tuberculosis. This has provided direct support for the current theory of Mycobacterium tuberculosis evolution, and suggests areas of investigation for the interaction of M tuberculosis with its host.
UR - http://www.scopus.com/inward/record.url?scp=4344712344&partnerID=8YFLogxK
U2 - 10.1016/S1473-3099(04)01133-8
DO - 10.1016/S1473-3099(04)01133-8
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C2 - 15336226
AN - SCOPUS:4344712344
SN - 1473-3099
VL - 4
SP - 584
EP - 592
JO - The Lancet Infectious Diseases
JF - The Lancet Infectious Diseases
IS - 9
ER -
