Tuberculosis: From prehistory to Robert Koch, as revealed by ancient DNA

Helen D. Donoghue; Mark Spigelman; Charles L. Greenblatt; Galit Lev-Maor; Gila Kahila Bar-Gal; Carney Matheson; Kim Vernon; Andreas G. Nerlich; Albert R. Zink

doi:10.1016/S1473-3099(04)01133-8

Tuberculosis: From prehistory to Robert Koch, as revealed by ancient DNA

Helen D. Donoghue^*
, Mark Spigelman
, Charles L. Greenblatt
, Galit Lev-Maor
, Gila Kahila Bar-Gal
, Carney Matheson
, Kim Vernon
, Andreas G. Nerlich
, Albert R. Zink

^*Corresponding author for this work

Institute for Medical Research Israel-Canada (IMRIC)

Research output: Contribution to journal › Review article › peer-review

160 Scopus citations

Abstract

During the past 10 years palaeomicrobiology, a new scientific discipline, has developed. The study of ancient pathogens by direct detection of their DNA has answered several historical questions and shown changes to pathogens over time. However, ancient DNA (aDNA) continues to be controversial and great care is needed to provide valid data. Here we review the most successful application of the technology, which is the study of tuberculosis. This has provided direct support for the current theory of Mycobacterium tuberculosis evolution, and suggests areas of investigation for the interaction of M tuberculosis with its host.

Original language	English
Pages (from-to)	584-592
Number of pages	9
Journal	The Lancet Infectious Diseases
Volume	4
Issue number	9
DOIs	https://doi.org/10.1016/S1473-3099(04)01133-8
State	Published - 1 Sep 2004

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SDG 3 Good Health and Well-being

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10.1016/S1473-3099(04)01133-8

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abstract = "During the past 10 years palaeomicrobiology, a new scientific discipline, has developed. The study of ancient pathogens by direct detection of their DNA has answered several historical questions and shown changes to pathogens over time. However, ancient DNA (aDNA) continues to be controversial and great care is needed to provide valid data. Here we review the most successful application of the technology, which is the study of tuberculosis. This has provided direct support for the current theory of Mycobacterium tuberculosis evolution, and suggests areas of investigation for the interaction of M tuberculosis with its host.",

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AU - Kahila Bar-Gal, Gila

AU - Matheson, Carney

AU - Vernon, Kim

AU - Nerlich, Andreas G.

AU - Zink, Albert R.

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Tuberculosis: From prehistory to Robert Koch, as revealed by ancient DNA

Abstract

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