Tuftelin mRNA is expressed in a human ameloblastoma tumor

D. Deutsch*, E. Fermon, J. Lustmann, L. Dafni, Z. Mao, V. Leytin, A. Palmon

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


RT-PCR, Southern blotting and DNA sequencing have established for the first time that tuftelin mRNA is expressed in human ameloblastoma tumor. The expression of amelogenin mRNA in ameloblastoma was also established, confirming earlier reports by Snead et al. These results corroborate, on a molecular level, the enamel organ epithelial origin of ameloblastoma. In view of the present results, it is interesting that previous studies have indicated that although ameloblastoma, a non-mineralized odontogenic tumor, transcribes amelogenin mRNA, amelogenin (and enamelin) proteins are not expressed in this tissue. However, in mineralizing odontogenic tumors, both these classes of proteins are expressed.

Original languageAmerican English
Pages (from-to)177-184
Number of pages8
JournalConnective Tissue Research
Issue number1-3
StatePublished - 1998


  • Ameloblastoma
  • Amelogenin mRNA
  • DNA sequencing
  • Odontogenic tumor
  • Tuftelin mRNA


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