Tumor microenvironment as target in cancer therapy

Reuven Reich; Claudiu T. Supuran; Eli Breuer

doi:10.1016/B978-0-12-800167-7.00017-1

Tumor microenvironment as target in cancer therapy

Reuven Reich, Claudiu T. Supuran, Eli Breuer

School of Pharmacy

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

6 Scopus citations

Abstract

The role of the microenvironment is of critical importance during the initiation and progression of carcinogenesis, both for understanding cancer biology and exploiting new knowledge for improved diagnostics and therapeutics at the cellular and molecular level. This summary emphasizes the most dynamic aspects of the microenvironment, namely tumor promoting enzymes and their inhibition. The enzymes mentioned are matrix metalloproteinases (MMPs) degrading connective tissue and carbonic anhydrases regulating pH level in the extracellular space. Additional enzymes reviewed are ectonucleotidases, such as autotaxin (ATX), CD73, and CD39. There is a short introduction to carbamoylphosphonates, inhibitors that regulate in vivo three kinds of zinc enzymes, MMP2, CAIX, and ATX, incapacitating the cancer.

Original language	English
Title of host publication	Annual Reports in Medicinal Chemistry
Publisher	Academic Press Inc.
Pages	269-284
Number of pages	16
DOIs	https://doi.org/10.1016/B978-0-12-800167-7.00017-1
State	Published - 2014

Publication series

Name	Annual Reports in Medicinal Chemistry
Volume	49
ISSN (Print)	0065-7743

Bibliographical note

Publisher Copyright:
© 2014 Elsevier Inc.

Keywords

Autotaxin
CD39
CD73
Carbamoylphosphonate
Carbonic anhydrase
Enzyme
Extracellular
Inhibitor
Matrix metalloproteinase
Microenvironment
Tumor

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/B978-0-12-800167-7.00017-1

Cite this

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title = "Tumor microenvironment as target in cancer therapy",

abstract = "The role of the microenvironment is of critical importance during the initiation and progression of carcinogenesis, both for understanding cancer biology and exploiting new knowledge for improved diagnostics and therapeutics at the cellular and molecular level. This summary emphasizes the most dynamic aspects of the microenvironment, namely tumor promoting enzymes and their inhibition. The enzymes mentioned are matrix metalloproteinases (MMPs) degrading connective tissue and carbonic anhydrases regulating pH level in the extracellular space. Additional enzymes reviewed are ectonucleotidases, such as autotaxin (ATX), CD73, and CD39. There is a short introduction to carbamoylphosphonates, inhibitors that regulate in vivo three kinds of zinc enzymes, MMP2, CAIX, and ATX, incapacitating the cancer.",

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AU - Supuran, Claudiu T.

AU - Breuer, Eli

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KW - Autotaxin

KW - CD39

KW - CD73

KW - Carbamoylphosphonate

KW - Carbonic anhydrase

KW - Enzyme

KW - Extracellular

KW - Inhibitor

KW - Matrix metalloproteinase

KW - Microenvironment

KW - Tumor

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Tumor microenvironment as target in cancer therapy

Abstract

Publication series

Bibliographical note

Keywords

UN SDGs

Access to Document

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