TY - JOUR
T1 - Tumorigenicity of benzo[a]pyrene 4,5-, 7,8-, 9,10- and 11,12-oxides in newborn mice
AU - Wislocki, Peter G.
AU - Kapitulnik, Jaime
AU - Levin, Wayne
AU - Conney, Allan H.
AU - Yagi, Haruhiko
AU - Jerina, Donald M.
PY - 1978/10
Y1 - 1978/10
N2 - Benzo[a]pyrene (BP) and its 4,5-, 7,8-, 9,10 and 11,12-oxides were tested for carcinogenicity by intraperitoneal injection into newborn mice. The mice were treated sequentially with 200, 400 and 800 nmol of hydrocarbon on days 1, 8 and 15 of life, and the animals were killed at 24 weeks of age. Mice treated with BP, BP 7,8-oxide and BP 11,12-oxide had a 93%, 72% and 20% incidence of pulmonary adenomas, respectively, with an average of 10.0, 2.1 and 0.32 adenomas/mouse, respectively. Eight percent of the control animals had pulinonary adenomas with an average of 0.08 adenomas per mouse. The moderate tumorigenic activity of the relatively unstable BP 7,8-oxide, together with earlier data on the strong carcinogenic activity of BP, 7,8-dihydrodiol, support the idea that BP 7,8-oxide is a proximate carcinogenic metabolite of BP in the newborn mouse.
AB - Benzo[a]pyrene (BP) and its 4,5-, 7,8-, 9,10 and 11,12-oxides were tested for carcinogenicity by intraperitoneal injection into newborn mice. The mice were treated sequentially with 200, 400 and 800 nmol of hydrocarbon on days 1, 8 and 15 of life, and the animals were killed at 24 weeks of age. Mice treated with BP, BP 7,8-oxide and BP 11,12-oxide had a 93%, 72% and 20% incidence of pulmonary adenomas, respectively, with an average of 10.0, 2.1 and 0.32 adenomas/mouse, respectively. Eight percent of the control animals had pulinonary adenomas with an average of 0.08 adenomas per mouse. The moderate tumorigenic activity of the relatively unstable BP 7,8-oxide, together with earlier data on the strong carcinogenic activity of BP, 7,8-dihydrodiol, support the idea that BP 7,8-oxide is a proximate carcinogenic metabolite of BP in the newborn mouse.
UR - http://www.scopus.com/inward/record.url?scp=0018198051&partnerID=8YFLogxK
U2 - 10.1016/S0304-3835(78)80038-X
DO - 10.1016/S0304-3835(78)80038-X
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C2 - 688201
AN - SCOPUS:0018198051
SN - 0304-3835
VL - 5
SP - 191
EP - 197
JO - Cancer Letters
JF - Cancer Letters
IS - 4
ER -