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Tuning Sodium Channel Blockers to the Near-Atomic Level
Sara Eyal
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Corresponding author for this work
School of Pharmacy
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Keyphrases
Lamotrigine
100%
Atomic Level
100%
Sodium Channel Blocker
100%
Nav Channels
80%
Antiepileptic Drugs
60%
Central Cavity
40%
Nav1.7
40%
Riluzole
40%
Physiological Processes
20%
Neuronal Processes
20%
Analgesic
20%
Mutational Analysis
20%
Docking Analysis
20%
Cannabidiol
20%
Structure-activity Relationship
20%
Improved Efficacy
20%
Local Anesthetics
20%
Cryogenic Electron Microscopy
20%
Ligand-free
20%
Pore Domain
20%
Pain Relief
20%
Clinical Drugs
20%
Lacosamide
20%
Membrane Excitability
20%
Drug Mechanism of Action
20%
3D-EEM
20%
Investigational Drugs
20%
Subtype Specificity
20%
Voltage-gated Sodium (Nav) Channels
20%
EM Reconstruction
20%
Pharmacology, Toxicology and Pharmaceutical Science
Lamictal
100%
Sodium Channel Blocking Agent
100%
Anticonvulsive Agent
40%
Riluzole
40%
Electron Microscopy
20%
Drug Action
20%
Structure Activity Relationship
20%
Cannabidiol
20%
Analgesic Agent
20%
Lacosamide
20%
Local Anesthetic Agent
20%
Antiarrhythmic Agent
20%
Investigational Drug
20%