Turning off Bacillus cereus quorum sensing system with peptidic analogs

Avishag Yehuda, Leyla Slamti, Racheli Bochnik-Tamir, Einav Malach, Didier Lereclus, Zvi Hayouka*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


We explored quenching of the PlcR-PapR quorum-sensing system in Bacillus cereus. We generated PapR7-peptidic derivatives that inhibit this system and thus the production of virulence factors, reflected by a loss in hemolytic activity, without affecting bacterial growth. To our knowledge, these peptides represent the first potent synthetic inhibitors of quorum-sensing in B. cereus.

Original languageAmerican English
Pages (from-to)9777-9780
Number of pages4
JournalChemical Communications
Issue number70
StatePublished - 2018

Bibliographical note

Publisher Copyright:
© 2018 The Royal Society of Chemistry.


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