TY - JOUR
T1 - Turning off Bacillus cereus quorum sensing system with peptidic analogs
AU - Yehuda, Avishag
AU - Slamti, Leyla
AU - Bochnik-Tamir, Racheli
AU - Malach, Einav
AU - Lereclus, Didier
AU - Hayouka, Zvi
N1 - Publisher Copyright:
© 2018 The Royal Society of Chemistry.
PY - 2018
Y1 - 2018
N2 - We explored quenching of the PlcR-PapR quorum-sensing system in Bacillus cereus. We generated PapR7-peptidic derivatives that inhibit this system and thus the production of virulence factors, reflected by a loss in hemolytic activity, without affecting bacterial growth. To our knowledge, these peptides represent the first potent synthetic inhibitors of quorum-sensing in B. cereus.
AB - We explored quenching of the PlcR-PapR quorum-sensing system in Bacillus cereus. We generated PapR7-peptidic derivatives that inhibit this system and thus the production of virulence factors, reflected by a loss in hemolytic activity, without affecting bacterial growth. To our knowledge, these peptides represent the first potent synthetic inhibitors of quorum-sensing in B. cereus.
UR - http://www.scopus.com/inward/record.url?scp=85052678020&partnerID=8YFLogxK
U2 - 10.1039/c8cc05496g
DO - 10.1039/c8cc05496g
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C2 - 30105347
AN - SCOPUS:85052678020
SN - 1359-7345
VL - 54
SP - 9777
EP - 9780
JO - Chemical Communications
JF - Chemical Communications
IS - 70
ER -