Two coupled enzymes perform in parallel the 'AND' and 'InhibAND' logic gate operations

Ronan Baron; Oleg Lioubashevski; Eugenii Katz; Tamara Niazov; Itamar Willner

doi:10.1039/b518205k

Two coupled enzymes perform in parallel the 'AND' and 'InhibAND' logic gate operations

Ronan Baron, Oleg Lioubashevski, Eugenii Katz, Tamara Niazov, Itamar Willner^*

^*Corresponding author for this work

Institute of Chemistry

Research output: Contribution to journal › Article › peer-review

70 Scopus citations

Abstract

The coupled activation of two enzymes: glucose dehydrogenase (GDH) and horseradish peroxidase (HRP), is used to construct the parallel-operating AND and InhibAND logic gates. The added substrates for the respective enzymes, glucose and H₂O₂, act as the gate inputs, while the biocatalytically generated NADH and gluconic acid provide the output signals that follow the operations of the gates. The two gates are generated in the same vial, thus allowing the logic operations to take place in parallel, and the simultaneous readout of the functions of the gates.

Original language	English
Pages (from-to)	989-991
Number of pages	3
Journal	Organic and Biomolecular Chemistry
Volume	4
Issue number	6
DOIs	https://doi.org/10.1039/b518205k
State	Published - 2006

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abstract = "The coupled activation of two enzymes: glucose dehydrogenase (GDH) and horseradish peroxidase (HRP), is used to construct the parallel-operating AND and InhibAND logic gates. The added substrates for the respective enzymes, glucose and H2O2, act as the gate inputs, while the biocatalytically generated NADH and gluconic acid provide the output signals that follow the operations of the gates. The two gates are generated in the same vial, thus allowing the logic operations to take place in parallel, and the simultaneous readout of the functions of the gates.",

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AU - Willner, Itamar

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Two coupled enzymes perform in parallel the 'AND' and 'InhibAND' logic gate operations

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