TY - JOUR
T1 - Two doses of SARS-CoV-2 vaccination induce robust immune responses to emerging SARS-CoV-2 variants of concern
AU - Medawar Laboratory Team
AU - OPTIC (Oxford Protective T cell Immunology for COVID-19) Clinical Group
AU - PITCH (Protective Immunity T cells in Health Care Worker) Study Group
AU - C-MORE/PHOSP-C Group
AU - Skelly, Donal T.
AU - Harding, Adam C.
AU - Gilbert-Jaramillo, Javier
AU - Knight, Michael L.
AU - Longet, Stephanie
AU - Brown, Anthony
AU - Adele, Sandra
AU - Adland, Emily
AU - Brown, Helen
AU - Chinnakannan, Senthil
AU - Donnison, Timothy
AU - Ali, Mohammad
AU - Rongkard, Patpong
AU - Pace, Matthew
AU - Zacharopoulou, Peny
AU - Robinson, Nicola
AU - Csala, Anna
AU - De Lara, Cathy
AU - Hutchings, Claire L.
AU - Mehta, Hema
AU - Lee, Lian Ni
AU - Edmans, Matthew
AU - Hackstein, Carl Philipp
AU - Phalora, Prabhjeet
AU - Li, Wenqin
AU - Phillips, Eloise
AU - Malone, Tom
AU - Ogbe, Ane
AU - Jay, Cecilia
AU - Tipoe, Timothy
AU - Tipton, Tom
AU - Stafford, Lizzie
AU - Mentzer, Alexander J.
AU - Johnson, Síle A.
AU - Amini, Ali
AU - Marjot, Thomas
AU - Dimitriadis, Stavros
AU - Simmons, Beatrice
AU - Deeks, Alexandra
AU - Kerneis, Sven
AU - Abuelgasim, Hibatullah
AU - Wilson, Robert
AU - Thomas, Sarah R.
AU - Watson, Adam
AU - Alhussni, Ahmed
AU - Cutteridge, Joseph
AU - Weeks, Esme
AU - Denly, Lucy
AU - Lillie, Katy
AU - Sigal, Alex
N1 - Publisher Copyright:
© 2021, The Author(s).
PY - 2021/12/1
Y1 - 2021/12/1
N2 - The extent to which immune responses to natural infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and immunization with vaccines protect against variants of concern (VOC) is of increasing importance. Accordingly, here we analyse antibodies and T cells of a recently vaccinated, UK cohort, alongside those recovering from natural infection in early 2020. We show that neutralization of the VOC compared to a reference isolate of the original circulating lineage, B, is reduced: more profoundly against B.1.351 than for B.1.1.7, and in responses to infection or a single dose of vaccine than to a second dose of vaccine. Importantly, high magnitude T cell responses are generated after two vaccine doses, with the majority of the T cell response directed against epitopes that are conserved between the prototype isolate B and the VOC. Vaccination is required to generate high potency immune responses to protect against these and other emergent variants.
AB - The extent to which immune responses to natural infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and immunization with vaccines protect against variants of concern (VOC) is of increasing importance. Accordingly, here we analyse antibodies and T cells of a recently vaccinated, UK cohort, alongside those recovering from natural infection in early 2020. We show that neutralization of the VOC compared to a reference isolate of the original circulating lineage, B, is reduced: more profoundly against B.1.351 than for B.1.1.7, and in responses to infection or a single dose of vaccine than to a second dose of vaccine. Importantly, high magnitude T cell responses are generated after two vaccine doses, with the majority of the T cell response directed against epitopes that are conserved between the prototype isolate B and the VOC. Vaccination is required to generate high potency immune responses to protect against these and other emergent variants.
UR - https://www.scopus.com/pages/publications/85114436194
U2 - 10.1038/s41467-021-25167-5
DO - 10.1038/s41467-021-25167-5
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C2 - 34404775
AN - SCOPUS:85114436194
SN - 2041-1723
VL - 12
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 5061
ER -
