Two opposing plasticity mechanisms pulling a single synapse

Ithai Rabinowitch*, Idan Segev

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

75 Scopus citations


Homeostatic synaptic plasticity (HSP) has been suggested to act as a negative feedback mechanism responsible for globally and uniformly scaling (up or down) the strength of all synapses in the neuron, in compensation for chronically aberrant (too low or too high) levels of activity. Such global scaling preserves the relative strengths of synapses and thus keeps 'Hebbian-like' memory traces (long-term potentiations, LTP, or depressions, LTD). However, new experimental findings demonstrate that HSP can operate locally, controlling each synapse individually. Seemingly, this finding implies that HSP can abolish any modification of synaptic strength (erase LTP/LTD). We propose that dendrites offer an inherent solution to this 'paradox' and that in fact local HSP might confer upon the neuron several surprising benefits, which are demonstrated using computer simulations.

Original languageAmerican English
Pages (from-to)377-383
Number of pages7
JournalTrends in Neurosciences
Issue number8
StatePublished - Aug 2008

Bibliographical note

Funding Information:
This work was supported by a grant donation by the Edmond J. Safra Foundation (‘Learning and Memory’) and by the NIH (IR01-MH59976–01A2) and the Israeli Science Foundation (10/256). I.R. was supported by a Horowitz Fund fellowship.


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