TY - JOUR
T1 - Type 2 diabetes has minimal effect on osseointegration of titanium implants in Psammomys obesus
AU - Casap, Nardy
AU - Nimri, Samer
AU - Ziv, Ehud
AU - Sela, Jona
AU - Samuni, Yuval
PY - 2008/5
Y1 - 2008/5
N2 - Objectives: Dental implants are routinely used with high success rates in generally healthy individuals. In contrast, their use in patients with uncontrolled diabetes mellitus (DM) remains controversial as altered bone healing around implants has been reported. The majority of reports addressing the issue of osseointegration of implants in animals were performed in β-cell cytotoxic-induced Type I diabetes. In this study, we assessed the osseointegration of implants in Gerbil Psammomys obesus, a model of nutritionally induced Type 2 DM. Materials and methods: Titanium implants were inserted into the tibial medullary space of 140 male diabetic and control animals. One, 2, 4, and 8 weeks after implantation the tibias were removed for histomorphometric evaluation, which included trabecular bone volumes (TBV) and osseointegration. Results: Two weeks following implantation, diabetic animals had slightly less mature bone when compared with control animals. This distinction was not present 4 weeks after implantation. Interestingly, no correlation was found between ossetointegration or TBV and glucose and insulin levels. Furthermore, no difference in osseointegration and TBV values was seen between the groups. The heterogeneity of serum glucose and insulin levels in this model and the possible role of insulin in bone metabolism are discussed. Conclusions: No significant difference in osseointegration and TBV was seen between diabetic and control P. obesus, a model of nutritionally induced Type 2 DM.
AB - Objectives: Dental implants are routinely used with high success rates in generally healthy individuals. In contrast, their use in patients with uncontrolled diabetes mellitus (DM) remains controversial as altered bone healing around implants has been reported. The majority of reports addressing the issue of osseointegration of implants in animals were performed in β-cell cytotoxic-induced Type I diabetes. In this study, we assessed the osseointegration of implants in Gerbil Psammomys obesus, a model of nutritionally induced Type 2 DM. Materials and methods: Titanium implants were inserted into the tibial medullary space of 140 male diabetic and control animals. One, 2, 4, and 8 weeks after implantation the tibias were removed for histomorphometric evaluation, which included trabecular bone volumes (TBV) and osseointegration. Results: Two weeks following implantation, diabetic animals had slightly less mature bone when compared with control animals. This distinction was not present 4 weeks after implantation. Interestingly, no correlation was found between ossetointegration or TBV and glucose and insulin levels. Furthermore, no difference in osseointegration and TBV values was seen between the groups. The heterogeneity of serum glucose and insulin levels in this model and the possible role of insulin in bone metabolism are discussed. Conclusions: No significant difference in osseointegration and TBV was seen between diabetic and control P. obesus, a model of nutritionally induced Type 2 DM.
KW - Animals
KW - Diabetes
KW - Implants
UR - http://www.scopus.com/inward/record.url?scp=42149167938&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0501.2007.01495.x
DO - 10.1111/j.1600-0501.2007.01495.x
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C2 - 18371104
AN - SCOPUS:42149167938
SN - 0905-7161
VL - 19
SP - 458
EP - 464
JO - Clinical Oral Implants Research
JF - Clinical Oral Implants Research
IS - 5
ER -