Tyrphostin-induced inhibition of p210(bcr-abl) tyrosine kinase activity induces K562 to differentiate

M. Anafi; A. Gazit; A. Zehavi; Y. Ben-Neriah; A. Levitzki

doi:10.1182/blood.v82.12.3524.3524

Tyrphostin-induced inhibition of p210(bcr-abl) tyrosine kinase activity induces K562 to differentiate

M. Anafi, A. Gazit, A. Zehavi, Y. Ben-Neriah, A. Levitzki^*

^*Corresponding author for this work

Department of Immunology and Cancer Research

Research output: Contribution to journal › Article › peer-review

120 Scopus citations

Abstract

We report on the potency of two Tyrphostin tyrosine kinase blockers, AG 1112 and AG 568, to inhibit p210(bcr-abl) tyrosine kinase activity in K562 cells, concomitant with the induction of erythroid differentiation. AG 568 and especially AG 1112 represent a specific group of nontoxic protein tyrosine kinase blockers among more than 1,400 tested. These compounds possess therapeutic potential for purging Philadelphia chromosome-positive cells in preparation for autologous bone marrow transplantation in chronic myelogenous leukemia.

Original language	English
Pages (from-to)	3524-3529
Number of pages	6
Journal	Blood
Volume	82
Issue number	12
DOIs	https://doi.org/10.1182/blood.v82.12.3524.3524
State	Published - 1993

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10.1182/blood.v82.12.3524.3524

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abstract = "We report on the potency of two Tyrphostin tyrosine kinase blockers, AG 1112 and AG 568, to inhibit p210(bcr-abl) tyrosine kinase activity in K562 cells, concomitant with the induction of erythroid differentiation. AG 568 and especially AG 1112 represent a specific group of nontoxic protein tyrosine kinase blockers among more than 1,400 tested. These compounds possess therapeutic potential for purging Philadelphia chromosome-positive cells in preparation for autologous bone marrow transplantation in chronic myelogenous leukemia.",

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AU - Gazit, A.

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AU - Ben-Neriah, Y.

AU - Levitzki, A.

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AB - We report on the potency of two Tyrphostin tyrosine kinase blockers, AG 1112 and AG 568, to inhibit p210(bcr-abl) tyrosine kinase activity in K562 cells, concomitant with the induction of erythroid differentiation. AG 568 and especially AG 1112 represent a specific group of nontoxic protein tyrosine kinase blockers among more than 1,400 tested. These compounds possess therapeutic potential for purging Philadelphia chromosome-positive cells in preparation for autologous bone marrow transplantation in chronic myelogenous leukemia.

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Tyrphostin-induced inhibition of p210(bcr-abl) tyrosine kinase activity induces K562 to differentiate

Abstract

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