Tyrphostins IV - Highly potent inhibitors of EGF receptor kinase. Structure-activity relationship study of 4-anilidoquinazolines

Aviv Gazit; Jeffrey Chen; App Harald; Gerald McMahon; Peter Hirth; Irit Chen; Alexander Levitzki

doi:10.1016/0968-0896(96)00107-1

Tyrphostins IV - Highly potent inhibitors of EGF receptor kinase. Structure-activity relationship study of 4-anilidoquinazolines

Aviv Gazit
, Jeffrey Chen
, App Harald
, Gerald McMahon
, Peter Hirth
, Irit Chen
, Alexander Levitzki^*

^*Corresponding author for this work

Alexander Silberman Institute of Life Sciences

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

Abstract

Potent 4-anilido-substituted quinazolines which potently inhibit epidermal growth factor receptor (EGFR) kinase were prepared. Structure-activity relationship studies reveal high sensitivity to substitution at the aniline ring.

Original language	English
Pages (from-to)	1203-1207
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry
Volume	4
Issue number	8
DOIs	https://doi.org/10.1016/0968-0896(96)00107-1
State	Published - Aug 1996

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10.1016/0968-0896(96)00107-1

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title = "Tyrphostins IV - Highly potent inhibitors of EGF receptor kinase. Structure-activity relationship study of 4-anilidoquinazolines",

abstract = "Potent 4-anilido-substituted quinazolines which potently inhibit epidermal growth factor receptor (EGFR) kinase were prepared. Structure-activity relationship studies reveal high sensitivity to substitution at the aniline ring.",

author = "Aviv Gazit and Jeffrey Chen and App Harald and Gerald McMahon and Peter Hirth and Irit Chen and Alexander Levitzki",

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AU - Gazit, Aviv

AU - Chen, Jeffrey

AU - Harald, App

AU - McMahon, Gerald

AU - Hirth, Peter

AU - Chen, Irit

AU - Levitzki, Alexander

PY - 1996/8

Y1 - 1996/8

N2 - Potent 4-anilido-substituted quinazolines which potently inhibit epidermal growth factor receptor (EGFR) kinase were prepared. Structure-activity relationship studies reveal high sensitivity to substitution at the aniline ring.

AB - Potent 4-anilido-substituted quinazolines which potently inhibit epidermal growth factor receptor (EGFR) kinase were prepared. Structure-activity relationship studies reveal high sensitivity to substitution at the aniline ring.

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ER -

Tyrphostins IV - Highly potent inhibitors of EGF receptor kinase. Structure-activity relationship study of 4-anilidoquinazolines

Abstract

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