Tyrphostins suppress the growth of psoriatic keratinocytes

Hannah Ben‐Bassat*, Daniel V. Vardi, Aviv Gazit, Sidney N. Klaus, Malka Chaouat, Zipora Hartzstark, Alexander Levitzki

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

Abstract Tyrosine kinase inhibitors of the tyrphostin family which block EGF receptor kinase are reported to arrest the growth of psoriatic keratinocytes in vitro. Three tyrphostins with the potency ratio AG555 >> AG18 >> AG814 were found to arrest growth with no adverse cytotoxic effects. The potency ratio to inhibit keratinocyte proliferation follows their potency to inhibit EGF receptor kinase activity in vitro. These compounds represent novel leads for the therapy of psoriasis.

Original languageEnglish
Pages (from-to)82-88
Number of pages7
JournalExperimental Dermatology
Volume4
Issue number2
DOIs
StatePublished - Apr 1995

Keywords

  • cultured keratinocytes
  • psoriasis
  • tyrosine kinase inhibitors

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