Tyrphostins suppress the growth of psoriatic keratinocytes

Hannah Ben‐Bassat; Daniel V. Vardi; Aviv Gazit; Sidney N. Klaus; Malka Chaouat; Zipora Hartzstark; Alexander Levitzki

doi:10.1111/j.1600-0625.1995.tb00227.x

Tyrphostins suppress the growth of psoriatic keratinocytes

Hannah Ben‐Bassat^*
, Daniel V. Vardi
, Aviv Gazit
, Sidney N. Klaus
, Malka Chaouat
, Zipora Hartzstark
, Alexander Levitzki

^*Corresponding author for this work

Alexander Silberman Institute of Life Sciences

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

Abstract Tyrosine kinase inhibitors of the tyrphostin family which block EGF receptor kinase are reported to arrest the growth of psoriatic keratinocytes in vitro. Three tyrphostins with the potency ratio AG555 >> AG18 >> AG814 were found to arrest growth with no adverse cytotoxic effects. The potency ratio to inhibit keratinocyte proliferation follows their potency to inhibit EGF receptor kinase activity in vitro. These compounds represent novel leads for the therapy of psoriasis.

Original language	English
Pages (from-to)	82-88
Number of pages	7
Journal	Experimental Dermatology
Volume	4
Issue number	2
DOIs	https://doi.org/10.1111/j.1600-0625.1995.tb00227.x
State	Published - Apr 1995

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

cultured keratinocytes
psoriasis
tyrosine kinase inhibitors

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10.1111/j.1600-0625.1995.tb00227.x

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title = "Tyrphostins suppress the growth of psoriatic keratinocytes",

abstract = "Abstract Tyrosine kinase inhibitors of the tyrphostin family which block EGF receptor kinase are reported to arrest the growth of psoriatic keratinocytes in vitro. Three tyrphostins with the potency ratio AG555 >> AG18 >> AG814 were found to arrest growth with no adverse cytotoxic effects. The potency ratio to inhibit keratinocyte proliferation follows their potency to inhibit EGF receptor kinase activity in vitro. These compounds represent novel leads for the therapy of psoriasis.",

keywords = "cultured keratinocytes, psoriasis, tyrosine kinase inhibitors",

author = "Hannah Ben‐Bassat and Vardi, \{Daniel V.\} and Aviv Gazit and Klaus, \{Sidney N.\} and Malka Chaouat and Zipora Hartzstark and Alexander Levitzki",

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doi = "10.1111/j.1600-0625.1995.tb00227.x",

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AU - Ben‐Bassat, Hannah

AU - Vardi, Daniel V.

AU - Gazit, Aviv

AU - Klaus, Sidney N.

AU - Chaouat, Malka

AU - Hartzstark, Zipora

AU - Levitzki, Alexander

PY - 1995/4

Y1 - 1995/4

N2 - Abstract Tyrosine kinase inhibitors of the tyrphostin family which block EGF receptor kinase are reported to arrest the growth of psoriatic keratinocytes in vitro. Three tyrphostins with the potency ratio AG555 >> AG18 >> AG814 were found to arrest growth with no adverse cytotoxic effects. The potency ratio to inhibit keratinocyte proliferation follows their potency to inhibit EGF receptor kinase activity in vitro. These compounds represent novel leads for the therapy of psoriasis.

AB - Abstract Tyrosine kinase inhibitors of the tyrphostin family which block EGF receptor kinase are reported to arrest the growth of psoriatic keratinocytes in vitro. Three tyrphostins with the potency ratio AG555 >> AG18 >> AG814 were found to arrest growth with no adverse cytotoxic effects. The potency ratio to inhibit keratinocyte proliferation follows their potency to inhibit EGF receptor kinase activity in vitro. These compounds represent novel leads for the therapy of psoriasis.

KW - cultured keratinocytes

KW - psoriasis

KW - tyrosine kinase inhibitors

UR - https://www.scopus.com/pages/publications/0028922430

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IS - 2

ER -

Tyrphostins suppress the growth of psoriatic keratinocytes

Abstract

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Keywords

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