TY - JOUR
T1 - Ubiquitination and degradation of the inhibitors of NF-kappaB.
AU - Kanarek, Naama
AU - London, Nir
AU - Schueler-Furman, Ora
AU - Ben-Neriah, Yinon
PY - 2010/2
Y1 - 2010/2
N2 - The key step in NF-kappaB activation is the release of the NF-kappaB dimers from their inhibitory proteins, achieved via proteolysis of the IkappaBs. This irreversible signaling step constitutes a commitment to transcriptional activation. The signal is eventually terminated through nuclear expulsion of NF-kappaB, the outcome of a negative feedback loop based on IkappaBalpha transcription, synthesis, and IkappaBalpha-dependent nuclear export of NF-kappaB (Karin and Ben-Neriah 2000). Here, we review the process of signal-induced IkappaB ubiquitination and degradation by comparing the degradation of several IkappaBs and discussing the characteristics of IkappaBs' ubiquitin machinery.
AB - The key step in NF-kappaB activation is the release of the NF-kappaB dimers from their inhibitory proteins, achieved via proteolysis of the IkappaBs. This irreversible signaling step constitutes a commitment to transcriptional activation. The signal is eventually terminated through nuclear expulsion of NF-kappaB, the outcome of a negative feedback loop based on IkappaBalpha transcription, synthesis, and IkappaBalpha-dependent nuclear export of NF-kappaB (Karin and Ben-Neriah 2000). Here, we review the process of signal-induced IkappaB ubiquitination and degradation by comparing the degradation of several IkappaBs and discussing the characteristics of IkappaBs' ubiquitin machinery.
UR - http://www.scopus.com/inward/record.url?scp=77957271488&partnerID=8YFLogxK
U2 - 10.1101/cshperspect.a000166
DO - 10.1101/cshperspect.a000166
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.systematicreview???
C2 - 20182612
AN - SCOPUS:77957271488
SN - 1943-0264
VL - 2
SP - a000166
JO - Cold Spring Harbor perspectives in biology
JF - Cold Spring Harbor perspectives in biology
IS - 2
ER -