Ubiquitination and degradation of the inhibitors of NF-kappaB.

Naama Kanarek*, Nir London, Ora Schueler-Furman, Yinon Ben-Neriah

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

102 Scopus citations


The key step in NF-kappaB activation is the release of the NF-kappaB dimers from their inhibitory proteins, achieved via proteolysis of the IkappaBs. This irreversible signaling step constitutes a commitment to transcriptional activation. The signal is eventually terminated through nuclear expulsion of NF-kappaB, the outcome of a negative feedback loop based on IkappaBalpha transcription, synthesis, and IkappaBalpha-dependent nuclear export of NF-kappaB (Karin and Ben-Neriah 2000). Here, we review the process of signal-induced IkappaB ubiquitination and degradation by comparing the degradation of several IkappaBs and discussing the characteristics of IkappaBs' ubiquitin machinery.

Original languageAmerican English
Pages (from-to)a000166
JournalCold Spring Harbor perspectives in biology
Issue number2
StatePublished - Feb 2010


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