Ultrashort Peptides for the Self-Assembly of an Antiviral Coating

Tan Hu, Michaela Kaganovich, Zohar Shpilt, Apurba Pramanik, Omer Agazani, Siyi Pan, Edit Tshuva, Meital Reches*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Antiviral compounds are important for generating sterile surfaces. Here, two extremely short peptides, DOPA-Phe-NH2 and DOPA-Phe(4F)-NH2 that can self-assemble into spherical nanoparticles with antiviral activity are presented. The peptide assemblies possess excellent antiviral activity against bacteriophage T4 with antiviral minimal inhibitory concentrations of 125 and 62.5 µg mL−1, for DOPA-Phe-NH2 and DOPA-Phe(4F)-NH2, respectively. When the peptide assemblies are applied on a glass substrate by drop-casting, they deactivate more than 99.9% of bacteriophage T4 and Canine coronavirus. Importantly, the peptide assemblies have low toxicity toward mammalian cells. Overall, the findings can provide a novel strategy for the design and development of antiviral coatings for a decreased risk of viral infections.

Original languageAmerican English
Article number2202161
JournalAdvanced Materials Interfaces
Issue number6
StatePublished - 23 Feb 2023

Bibliographical note

Publisher Copyright:
© 2023 The Authors. Advanced Materials Interfaces published by Wiley-VCH GmbH.


  • antiviral
  • bacteriophage T4
  • nanoparticles
  • peptides
  • self-assembly


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