Ultrashort Peptides for the Self-Assembly of an Antiviral Coating

Tan Hu; Michaela Kaganovich; Zohar Shpilt; Apurba Pramanik; Omer Agazani; Siyi Pan; Edit Tshuva; Meital Reches

doi:10.1002/admi.202202161

Ultrashort Peptides for the Self-Assembly of an Antiviral Coating

Tan Hu, Michaela Kaganovich, Zohar Shpilt, Apurba Pramanik, Omer Agazani, Siyi Pan, Edit Tshuva, Meital Reches^*

^*Corresponding author for this work

Institute of Chemistry

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Antiviral compounds are important for generating sterile surfaces. Here, two extremely short peptides, DOPA-Phe-NH₂ and DOPA-Phe(4F)-NH₂ that can self-assemble into spherical nanoparticles with antiviral activity are presented. The peptide assemblies possess excellent antiviral activity against bacteriophage T4 with antiviral minimal inhibitory concentrations of 125 and 62.5 µg mL⁻¹, for DOPA-Phe-NH₂ and DOPA-Phe(4F)-NH₂, respectively. When the peptide assemblies are applied on a glass substrate by drop-casting, they deactivate more than 99.9% of bacteriophage T4 and Canine coronavirus. Importantly, the peptide assemblies have low toxicity toward mammalian cells. Overall, the findings can provide a novel strategy for the design and development of antiviral coatings for a decreased risk of viral infections.

Original language	English
Article number	2202161
Journal	Advanced Materials Interfaces
Volume	10
Issue number	6
DOIs	https://doi.org/10.1002/admi.202202161
State	Published - 23 Feb 2023

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Publisher Copyright:
© 2023 The Authors. Advanced Materials Interfaces published by Wiley-VCH GmbH.

Keywords

antiviral
bacteriophage T4
nanoparticles
peptides
self-assembly

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title = "Ultrashort Peptides for the Self-Assembly of an Antiviral Coating",

abstract = "Antiviral compounds are important for generating sterile surfaces. Here, two extremely short peptides, DOPA-Phe-NH2 and DOPA-Phe(4F)-NH2 that can self-assemble into spherical nanoparticles with antiviral activity are presented. The peptide assemblies possess excellent antiviral activity against bacteriophage T4 with antiviral minimal inhibitory concentrations of 125 and 62.5 µg mL−1, for DOPA-Phe-NH2 and DOPA-Phe(4F)-NH2, respectively. When the peptide assemblies are applied on a glass substrate by drop-casting, they deactivate more than 99.9% of bacteriophage T4 and Canine coronavirus. Importantly, the peptide assemblies have low toxicity toward mammalian cells. Overall, the findings can provide a novel strategy for the design and development of antiviral coatings for a decreased risk of viral infections.",

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AU - Hu, Tan

AU - Kaganovich, Michaela

AU - Shpilt, Zohar

AU - Pramanik, Apurba

AU - Agazani, Omer

AU - Pan, Siyi

AU - Tshuva, Edit

AU - Reches, Meital

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N2 - Antiviral compounds are important for generating sterile surfaces. Here, two extremely short peptides, DOPA-Phe-NH2 and DOPA-Phe(4F)-NH2 that can self-assemble into spherical nanoparticles with antiviral activity are presented. The peptide assemblies possess excellent antiviral activity against bacteriophage T4 with antiviral minimal inhibitory concentrations of 125 and 62.5 µg mL−1, for DOPA-Phe-NH2 and DOPA-Phe(4F)-NH2, respectively. When the peptide assemblies are applied on a glass substrate by drop-casting, they deactivate more than 99.9% of bacteriophage T4 and Canine coronavirus. Importantly, the peptide assemblies have low toxicity toward mammalian cells. Overall, the findings can provide a novel strategy for the design and development of antiviral coatings for a decreased risk of viral infections.

AB - Antiviral compounds are important for generating sterile surfaces. Here, two extremely short peptides, DOPA-Phe-NH2 and DOPA-Phe(4F)-NH2 that can self-assemble into spherical nanoparticles with antiviral activity are presented. The peptide assemblies possess excellent antiviral activity against bacteriophage T4 with antiviral minimal inhibitory concentrations of 125 and 62.5 µg mL−1, for DOPA-Phe-NH2 and DOPA-Phe(4F)-NH2, respectively. When the peptide assemblies are applied on a glass substrate by drop-casting, they deactivate more than 99.9% of bacteriophage T4 and Canine coronavirus. Importantly, the peptide assemblies have low toxicity toward mammalian cells. Overall, the findings can provide a novel strategy for the design and development of antiviral coatings for a decreased risk of viral infections.

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Ultrashort Peptides for the Self-Assembly of an Antiviral Coating

Abstract

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Keywords

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