TY - JOUR
T1 - Undecided membrane proteins insert in random topologies. Up, down and sideways
T2 - It does not really matter
AU - Schuldiner, Shimon
PY - 2012/6
Y1 - 2012/6
N2 - It is usually assumed that to ensure proper function, membrane proteins must be inserted in a unique topology. However, a number of dimeric small multidrug transporters can function in the membrane in various topologies. Thus, the dimers can be a random mixture of NiCi (N and C termini facing the cell cytoplasm) and NoCo (N and C termini facing the outside) orientation. In addition, the dimer functions whether the two protomers are parallel (N and C termini of both protomers on the same side of the membrane) or antiparallel (N and C termini of each protomer on opposite sides of the membrane). This unique phenomenon provides strong support for a simple mechanism of transport where the directionality is determined solely by the driving force.
AB - It is usually assumed that to ensure proper function, membrane proteins must be inserted in a unique topology. However, a number of dimeric small multidrug transporters can function in the membrane in various topologies. Thus, the dimers can be a random mixture of NiCi (N and C termini facing the cell cytoplasm) and NoCo (N and C termini facing the outside) orientation. In addition, the dimer functions whether the two protomers are parallel (N and C termini of both protomers on the same side of the membrane) or antiparallel (N and C termini of each protomer on opposite sides of the membrane). This unique phenomenon provides strong support for a simple mechanism of transport where the directionality is determined solely by the driving force.
UR - http://www.scopus.com/inward/record.url?scp=84861926761&partnerID=8YFLogxK
U2 - 10.1016/j.tibs.2012.02.006
DO - 10.1016/j.tibs.2012.02.006
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C2 - 22444835
AN - SCOPUS:84861926761
SN - 0968-0004
VL - 37
SP - 215
EP - 219
JO - Trends in Biochemical Sciences
JF - Trends in Biochemical Sciences
IS - 6
ER -