Unequal cell division as a driving force during differentiation

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Unequal cell division, leading to daughter cells of different sizes, is a common event during development. We have formulated a model that shows how different cell sizes can lead to significant differences in the expression of an activator gene. The model is based on well-known aspects of the regulation of gene expression, specifically the existence of multiple regulatory sites, positive autoregulation, and the short half-life of regulatory proteins. Thus the daughter cells may follow distinct differentiation pathways even if there were no localized determinants in the mother cell.

Original languageAmerican English
Pages (from-to)85-95
Number of pages11
JournalJournal of Theoretical Biology
Issue number1
StatePublished - 1993
Externally publishedYes


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