Unique sequences in the env gene of avian hemangioma retrovirus are responsible for cytotoxicity and endothelial cell perturbation

Haim Burstein, Resnick Roguel Nitzan, Judith Hamburger, Gila Arad, Mertyn Malkinson, Moshe Kotler*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

An avian retrovirus isolated from spontaneous cavernous hemangiomas of layer hens codes for an env protein that induces a cytopathic effect on a wide variety of cultured avian and mammalian cells and also causes thrombogenicity of endothelial cells. Sequence analysis of the avian hemangioma inducing virus revealed unique elements in both its env gene and its LTR. We propose that these elements are responsible for the biological and pathogenic characteristics of the virus.

Original languageEnglish
Pages (from-to)512-516
Number of pages5
JournalVirology
Volume179
Issue number1
DOIs
StatePublished - Nov 1990

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