Unique sequences in the env gene of avian hemangioma retrovirus are responsible for cytotoxicity and endothelial cell perturbation

Haim Burstein; Resnick Roguel Nitzan; Judith Hamburger; Gila Arad; Mertyn Malkinson; Moshe Kotler

doi:10.1016/0042-6822(90)90327-N

Unique sequences in the env gene of avian hemangioma retrovirus are responsible for cytotoxicity and endothelial cell perturbation

Haim Burstein
, Resnick Roguel Nitzan
, Judith Hamburger
, Gila Arad
, Mertyn Malkinson
, Moshe Kotler^*

^*Corresponding author for this work

Institute for Medical Research Israel-Canada (IMRIC)

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

An avian retrovirus isolated from spontaneous cavernous hemangiomas of layer hens codes for an env protein that induces a cytopathic effect on a wide variety of cultured avian and mammalian cells and also causes thrombogenicity of endothelial cells. Sequence analysis of the avian hemangioma inducing virus revealed unique elements in both its env gene and its LTR. We propose that these elements are responsible for the biological and pathogenic characteristics of the virus.

Original language	English
Pages (from-to)	512-516
Number of pages	5
Journal	Virology
Volume	179
Issue number	1
DOIs	https://doi.org/10.1016/0042-6822(90)90327-N
State	Published - Nov 1990

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title = "Unique sequences in the env gene of avian hemangioma retrovirus are responsible for cytotoxicity and endothelial cell perturbation",

abstract = "An avian retrovirus isolated from spontaneous cavernous hemangiomas of layer hens codes for an env protein that induces a cytopathic effect on a wide variety of cultured avian and mammalian cells and also causes thrombogenicity of endothelial cells. Sequence analysis of the avian hemangioma inducing virus revealed unique elements in both its env gene and its LTR. We propose that these elements are responsible for the biological and pathogenic characteristics of the virus.",

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AU - Burstein, Haim

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AU - Hamburger, Judith

AU - Arad, Gila

AU - Malkinson, Mertyn

AU - Kotler, Moshe

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AB - An avian retrovirus isolated from spontaneous cavernous hemangiomas of layer hens codes for an env protein that induces a cytopathic effect on a wide variety of cultured avian and mammalian cells and also causes thrombogenicity of endothelial cells. Sequence analysis of the avian hemangioma inducing virus revealed unique elements in both its env gene and its LTR. We propose that these elements are responsible for the biological and pathogenic characteristics of the virus.

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Unique sequences in the env gene of avian hemangioma retrovirus are responsible for cytotoxicity and endothelial cell perturbation

Abstract

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