Universality of biochemical feedback and its application to immune cells

Amir Erez, Tommy A. Byrd, Robert M. Vogel, Grégoire Altan-Bonnet, Andrew Mugler

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

We map a class of well-mixed stochastic models of biochemical feedback in steady state to the mean-field Ising model near the critical point. The mapping provides an effective temperature, magnetic field, order parameter, and heat capacity that can be extracted from biological data without fitting or knowledge of the underlying molecular details. We demonstrate this procedure on fluorescence data from mouse T cells, which reveals distinctions between how the cells respond to different drugs. We also show that the heat capacity allows inference of the absolute molecule number from fluorescence intensity. We explain this result in terms of the underlying fluctuations, and we demonstrate the generality of our work.

Original languageAmerican English
Article number022422
JournalPhysical Review E
Volume99
Issue number2
DOIs
StatePublished - 26 Feb 2019
Externally publishedYes

Bibliographical note

Publisher Copyright:
© 2019 American Physical Society.

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