Unveiling Novel Synthetic Pathways through Brook Rearrangement

Mohamed Agbaria, Nwar Egbaria, Zackaria Nairoukh*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The Brook rearrangement is a valuable synthetic tool that facilitates the controlled construction of complex molecules. Conventionally, it generates carbanion intermediates utilized in subsequent functionalization reactions. In this Review, we will explore recent advancements in the Brook rearrangement that extend beyond the traditional functionalization reactions. Specifically, we will highlight its involvement in unusual bonds cleavage, annulation reactions, and dearomatization efforts. The novelty of this rearrangement is underscored by showcasing its most recent applications.

Original languageAmerican English
StateAccepted/In press - 2024

Bibliographical note

Publisher Copyright:
© 2024 Georg Thieme Verlag. All rights reserved.


  • Anion relay chemistry
  • Brook rearrangement
  • Complex molecules
  • Silyl migration
  • Synthetic methods


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