Up-regulation of AMP-activated protein kinase in cancer cell lines is mediated through c-Src activation

Sarit Mizrachy-Schwartz, Noam Cohen, Shoshana Klein, Nataly Kravchenko-Balasha, Alexander Levitzki*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

We report that the activation level of AMP-dependent protein kinase AMPK is elevated in cancer cell lines as a hallmark of their transformed state. In OVCAR3 and A431 cells, c-Src signals through protein kinase Cα, phospholipase Cγ, and LKB1 to AMPK. AMPK controls internal ribosome entry site (IRES) dependent translation in these cells. We suggest that AMPK activation via PKC might be a general mechanism to regulate IRES-dependent translation in cancer cells.

Original languageAmerican English
Pages (from-to)15268-15277
Number of pages10
JournalJournal of Biological Chemistry
Volume286
Issue number17
DOIs
StatePublished - 29 Apr 2011

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