TY - JOUR
T1 - Up-regulation of AMP-activated protein kinase in cancer cell lines is mediated through c-Src activation
AU - Mizrachy-Schwartz, Sarit
AU - Cohen, Noam
AU - Klein, Shoshana
AU - Kravchenko-Balasha, Nataly
AU - Levitzki, Alexander
PY - 2011/4/29
Y1 - 2011/4/29
N2 - We report that the activation level of AMP-dependent protein kinase AMPK is elevated in cancer cell lines as a hallmark of their transformed state. In OVCAR3 and A431 cells, c-Src signals through protein kinase Cα, phospholipase Cγ, and LKB1 to AMPK. AMPK controls internal ribosome entry site (IRES) dependent translation in these cells. We suggest that AMPK activation via PKC might be a general mechanism to regulate IRES-dependent translation in cancer cells.
AB - We report that the activation level of AMP-dependent protein kinase AMPK is elevated in cancer cell lines as a hallmark of their transformed state. In OVCAR3 and A431 cells, c-Src signals through protein kinase Cα, phospholipase Cγ, and LKB1 to AMPK. AMPK controls internal ribosome entry site (IRES) dependent translation in these cells. We suggest that AMPK activation via PKC might be a general mechanism to regulate IRES-dependent translation in cancer cells.
UR - http://www.scopus.com/inward/record.url?scp=79955419135&partnerID=8YFLogxK
U2 - 10.1074/jbc.M110.211813
DO - 10.1074/jbc.M110.211813
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C2 - 21245141
AN - SCOPUS:79955419135
SN - 0021-9258
VL - 286
SP - 15268
EP - 15277
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 17
ER -
