Up-regulation of AMP-activated protein kinase in cancer cell lines is mediated through c-Src activation

Sarit Mizrachy-Schwartz; Noam Cohen; Shoshana Klein; Nataly Kravchenko-Balasha; Alexander Levitzki

doi:10.1074/jbc.M110.211813

Up-regulation of AMP-activated protein kinase in cancer cell lines is mediated through c-Src activation

Sarit Mizrachy-Schwartz
, Noam Cohen
, Shoshana Klein
, Nataly Kravchenko-Balasha
, Alexander Levitzki^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

We report that the activation level of AMP-dependent protein kinase AMPK is elevated in cancer cell lines as a hallmark of their transformed state. In OVCAR3 and A431 cells, c-Src signals through protein kinase Cα, phospholipase Cγ, and LKB1 to AMPK. AMPK controls internal ribosome entry site (IRES) dependent translation in these cells. We suggest that AMPK activation via PKC might be a general mechanism to regulate IRES-dependent translation in cancer cells.

Original language	English
Pages (from-to)	15268-15277
Number of pages	10
Journal	Journal of Biological Chemistry
Volume	286
Issue number	17
DOIs	https://doi.org/10.1074/jbc.M110.211813
State	Published - 29 Apr 2011

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10.1074/jbc.M110.211813

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AU - Levitzki, Alexander

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AB - We report that the activation level of AMP-dependent protein kinase AMPK is elevated in cancer cell lines as a hallmark of their transformed state. In OVCAR3 and A431 cells, c-Src signals through protein kinase Cα, phospholipase Cγ, and LKB1 to AMPK. AMPK controls internal ribosome entry site (IRES) dependent translation in these cells. We suggest that AMPK activation via PKC might be a general mechanism to regulate IRES-dependent translation in cancer cells.

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Up-regulation of AMP-activated protein kinase in cancer cell lines is mediated through c-Src activation

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