Uptake and degradation of a polypeptide antigen by stimulated and unstimulated macrophages from responder and non responder mice

R. Gallily, H. Eliahu

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5 Scopus citations

Abstract

An increase in the level of acid phosphatase, β glucuronidase and cathepsin D in macrophages was obtained by cultivating the cells in medium containing high serum concentration and by injecting macrophage donors with thioglycollate. A high level of the 3 hydrolytic enzymes in the stimulated macrophages does not correlate with a high uptake or degradation of the polypeptide antigen (TG) PRO--L. Moreover, macrophages with a low level of enzymes (unstimulated cells) pinocytose and degrade (TG) PRO--L more efficiently than macrophages with a high content of hydrolases. Unstimulated macrophages from responder (SJL) mice pinocytose and degrade (TG) PRO--L more efficiently than macrophages from the nonresponder (DBA/1) animals although the two cell populations had similar levels of hydrolases.

Original languageEnglish
Pages (from-to)603-612
Number of pages10
JournalImmunology
Volume26
Issue number3
StatePublished - 1974

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