Abstract
An increase in the level of acid phosphatase, β glucuronidase and cathepsin D in macrophages was obtained by cultivating the cells in medium containing high serum concentration and by injecting macrophage donors with thioglycollate. A high level of the 3 hydrolytic enzymes in the stimulated macrophages does not correlate with a high uptake or degradation of the polypeptide antigen (TG) PRO--L. Moreover, macrophages with a low level of enzymes (unstimulated cells) pinocytose and degrade (TG) PRO--L more efficiently than macrophages with a high content of hydrolases. Unstimulated macrophages from responder (SJL) mice pinocytose and degrade (TG) PRO--L more efficiently than macrophages from the nonresponder (DBA/1) animals although the two cell populations had similar levels of hydrolases.
Original language | English |
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Pages (from-to) | 603-612 |
Number of pages | 10 |
Journal | Immunology |
Volume | 26 |
Issue number | 3 |
State | Published - 1974 |