Urea nitrate and nitrourea: powerful and regioselective aromatic nitration agents

Joseph Almog*, Asne Klein, Anat Sokol, Yoel Sasson, Dana Sonenfeld, Tsippy Tamiri

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

Urea nitrate (UN) and nitrourea (NU), easily prepared from urea and nitric acid, convert deactivated aromatic compounds to the corresponding nitrated derivatives with a high yield and a high regioselectivity under very mild conditions. The performance of the two reagents is quite similar indicating that NU is an intermediate in the UN nitration process.

Original languageEnglish
Pages (from-to)8651-8652
Number of pages2
JournalTetrahedron Letters
Volume47
Issue number49
DOIs
StatePublished - 4 Dec 2006

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